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Dimitrios Tsikas
Hannover Medical School
454Publications
50H-index
11.3kCitations
Publications 454
Newest
#1Harrina Erlianti Rahardjo (UI: University of Indonesia)H-Index: 3
#2Stefan Ückert (MHH: Hannover Medical School)H-Index: 30
Last.George T. Kedia (MHH: Hannover Medical School)H-Index: 8
view all 7 authors...
#1Erik Hanff (MHH: Hannover Medical School)H-Index: 9
#2Alexander Bollenbach (MHH: Hannover Medical School)H-Index: 3
Last.Dimitrios Tsikas (MHH: Hannover Medical School)H-Index: 50
view all 5 authors...
Gas chromatography–mass spectrometry (GC–MS) methods were developed, validated and used to measure serum spermidine (SPD) and putrescine (PUT) in 9 seropositive Helicobacter pylori (Hp +) and 18 seronegative Helicobacter pylori (Hp −) subjects (31–105 years). Homoarginine (hArg) was also measured by GC–MS. There were no statistical differences (unpaired t test) between the Hp + and Hp − subjects with respect to the serum concentrations of SPD (67.6 ± 40.3 vs. 93.7 ± 37.7 nM, P = 0.109), PUT (220...
#1Erik Hanff (MHH: Hannover Medical School)H-Index: 9
#2Mohammad Yusof Said (UMCG: University Medical Center Groningen)
Last.Dimitrios Tsikas (MHH: Hannover Medical School)H-Index: 50
view all 10 authors...
l-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and l-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipients (RTR) compared to healthy subjects. In adults, hArg emerged as a novel risk factor for renal and cardiovascular adverse outcome. Urinary GAA was found to be lower in children and adolescents with kidney transplants compared to healthy controls. W...
#1Adrian PostH-Index: 1
#2M. Yusof SaidH-Index: 3
Last.van Harry GoorH-Index: 62
view all 15 authors...
Taurine is a sulfur containing nutrient that has been shown to protect against oxidative stress, which has been implicated in the pathophysiology leading to late graft failure after renal transplantation. We prospectively investigated whether high urinary taurine excretion, reflecting high taurine intake, is associated with low risk for development of late graft failure in renal transplant recipients (RTR). Urinary taurine excretion was measured in a longitudinal cohort of 678 stable RTR. Prospe...
#1Stefan Ückert (MHH: Hannover Medical School)H-Index: 30
#2George T. Kedia (MHH: Hannover Medical School)H-Index: 8
Last.Markus A. Kuczyk (MHH: Hannover Medical School)H-Index: 41
view all 6 authors...
Objectives The benign prostatic syndrome, comprising lower urinary tract symptomatology secondary to benign prostatic hyperplasia/enlargement, represents a major health care issue in westernized countries. The pharmacological management involves alpha-adrenoceptor antagonists, intervention into the hormonal control of prostate growth using inhibitors of the enzyme 5-alpha-reductase, and stimulation of the nitric oxide/cyclic GMP pathway by tadalafil, an inhibitor of the phosphodiesterase type 5.
This study investigated the exercise-induced changes in oxidative stress, nitric oxide (NO) metabolism and amino acid profile in plasma of omnivorous (OMN, n = 25), lacto-ovo-vegetarian (LOV, n = 25) and vegan (VEG, n = 23) recreational runners. Oxidative stress was measured as malondialdehyde (MDA), NO as nitrite and nitrate, and various amino acids, including homoarginine and guanidinoacetate, the precursor of creatine. All analytes were measured by validated stable-isotope dilution gas chroma...
#1Alexander Bollenbach (MHH: Hannover Medical School)H-Index: 3
#2Kathrin Cordts (UHH: University of Hamburg)H-Index: 5
Last.Dimitrios Tsikas (MHH: Hannover Medical School)H-Index: 50
view all 7 authors...
Abstract l -Homoarginine (hArg) is biosynthesized from l -arginine (Arg) and l -lysine (Lys) by arginine:glycine amidinotransferase (AGAT). AGAT also catalyzes the formation of guanidinoacetate (GAA) from Arg and glycine (Gly). GAA is converted to creatine ( N -methyl guanidinoacetate) by guanidinoacetate N -methyl-transferase (GAMT). Low circulating and excretory concentrations of hArg are associated with worse cardiovascular outcome and mortality. hArg is a poor substrate of nitric oxide synth...
#1Alexander Bollenbach (MHH: Hannover Medical School)H-Index: 3
Last.Dimitrios TsikasH-Index: 50
view all 4 authors...
Asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) are risk factors for the cardiovascular and renal systems. There is a paucity of data in humans regarding variations of protein L-arginine (Arg) methylation leading to ADMA and SDMA. In this study, we introduced and used Arg dimethylation indices based on the creatinine-corrected urinary excretion of SDMA and ADMA, and its major metabolite dimethylamine (DMA). The main objective of the present study was to assess whether, an...
#1M. Yusof Said (UG: University of Groningen)H-Index: 3
#2Alexander Bollenbach (MHH: Hannover Medical School)H-Index: 3
Last.van Harry Goor (UG: University of Groningen)H-Index: 62
view all 12 authors...
Cardiovascular disease (CVD) is the leading cause of death in renal transplant recipients (RTR). Elevated plasma asymmetric dimethylarginine (pADMA), an endogenous nitric oxide synthase inhibitor produced from the turnover of methylated arginine moieties in proteins, is a risk factor for CVD and mortality. It is unknown how urinary ADMA excretion (uADMA), one of the main ADMA elimination routes, is associated with long-term survival. Furthermore, the association of pADMA and uADMA with markers f...
#2Erik HanffH-Index: 9
Last.Dimitrios TsikasH-Index: 50
view all 4 authors...
The importance of l-arginine (Arg) and relatives, including l-homoarginine (hArg) and asymmetric dimethylarginine (ADMA), in humans infected with Helicobacter pylori (Hp) is little understood. ADMA is produced by asymmetric dimethylation of the guanidine group of Arg residues in certain proteins and is released by proteolysis. High concentrations of circulating free ADMA are considered a risk factor for morbidity and mortality in adults. This risk is considered to arise from the inhibition of th...
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