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Christopher A. Siedlecki
Pennsylvania State University
ChemistryMaterials scienceBiomaterialMedicineAdhesion
100Publications
29H-index
2,981Citations
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Publications 98
Newest
#1Li-Chong Xu (PSU: Pennsylvania State University)H-Index: 20
#2Chen Chen (PSU: Pennsylvania State University)H-Index: 14
Last. Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 29
view all 7 authors...
Biomaterial-associated microbial infection and thrombosis represent major issues to the success of long-term use of implantable blood-contacting medical devices. The development of new poly[bis(octafluoropentoxy) phosphazene (OFP) biomaterials provides new routes for combatting microbial infection and thrombosis. However, the limited mechanical properties of OFP to date render them unsuitable for application in medical devices and inhibit any attempts at subsequent surface topography modificatio...
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#1McKayla K.J. Nicol (PSU: Pennsylvania State University)
#2Timothy R. Brubaker (PSU: Pennsylvania State University)H-Index: 2
Last. S.D. Knecht (PSU: Pennsylvania State University)H-Index: 6
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Emergence and spread of antibiotic resistance calls for development of non-chemical treatment options for bacterial infections. Plasma medicine applies low-temperature plasma (LTP) physics to address biomedical problems such as wound healing and tumor suppression. LTP has also been used for surface disinfection. However, there is still much to be learned regarding the effectiveness of LTP on bacteria in suspension in liquids, and especially on porous surfaces. We investigated the efficacy of LTP...
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Last. S.D. KnechtH-Index: 6
view all 8 authors...
Plasma medicine is a rapidly expanding field that utilizes non-equilibrium plasma discharges at atmospheric conditions or in liquids for clinical applications. There is significant interest in the production of plasma in the liquid phase for wastewater treatment, agricultural applications, and medical purposes. However, little investigation has been done about the effects of dielectric coatings on submerged electrodes, which is of significant interest to limit electrical current flow in the liqu...
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#1Li-Chong Xu (PSU: Pennsylvania State University)H-Index: 20
Last. Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 29
view all 2 authors...
Abstract Medical devices have been widely used in modern healthcare, but the device-centered microbial infections still remain a significant problem and result in increased levels of morbidity and mortality for patients. Bacterial adhesion is the critical step in the pathogenesis of biomaterial-associated infection. Understanding the mechanisms of bacterial interaction with biomaterial surface is important for controlling bacterial adhesion and biofilm formation and preventing biomaterial-associ...
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#1Maud Gorbet (UW: University of Waterloo)H-Index: 12
#2Claudia SperlingH-Index: 15
Last. Michael V. Sefton (U of T: University of Toronto)H-Index: 42
view all 6 authors...
Abstract Following protein adsorption/activation which is the first step after the contact of material surfaces and whole blood (part 2), fibrinogen is converted to fibrin and platelets become activated and assembled in the form of a thrombus. This thrombus formation is the key feature that needs to be minimized in the creation of materials with low thrombogenicity. Further aspects of blood compatibility that are important on their own are complement and leukocyte activation which are also impor...
3 CitationsSource
#1Maud Gorbet (UW: University of Waterloo)H-Index: 12
#2Claudia SperlingH-Index: 15
Last. Michael V. Sefton (U of T: University of Toronto)H-Index: 42
view all 6 authors...
Despite >50 years of study, there are no materials that are considered truly nonthrombogenic. Some materials minimize protein adsorption or cell adhesion while others actively inhibit thrombin generation through heparinization. Nonetheless the problem of biomaterial associated thrombogenicity remains. While once an active area of research, the problem has not only not been solved, it has also been largely abandoned. It is considered too hard or efforts attack only one particular aspect of the pr...
1 CitationsSource
#1Choon-Sik Jhun (PSU: Pennsylvania State University)H-Index: 7
#2Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 29
Last. Gerson Rosenberg (PSU: Pennsylvania State University)H-Index: 23
view all 10 authors...
: Despite the prevailing use of the continuous flow left ventricular assist devices (cf-LVAD), acquired von Willebrand syndrome (AvWS) associated with cf-LVAD still remains a major complication. As AvWS is known to be dependent on shear stress (τ) and exposure time (texp ), this study examined the degradation of high molecular weight multimers (HMWM) of von Willebrand factor (vWF) in terms of τ and texp . Two custom apparatus, i.e., capillary-tubing-type degrader (CTD) and Taylor-Couette-type de...
2 CitationsSource
#1Qilong Feng (WVU: West Virginia University)H-Index: 1
#2Christian J. Stork (WVU: West Virginia University)H-Index: 1
Last. Pingnian He (WVU: West Virginia University)H-Index: 21
view all 14 authors...
KEY POINTS: Circulating microparticles (MPs) are elevated in many cardiovascular diseases and have been considered as biomarkers of disease prognosis; however, current knowledge of MP functions has been mainly derived from in vitro studies and their precise impact on vascular inflammation and disease progression remains obscure. Using a diabetic rat model, we identified a >130-fold increase in MPs in plasma of diabetic rats compared to normal rats, the majority of which circulated as aggregates,...
1 CitationsSource
#1Li-Chong Xu (PSU: Pennsylvania State University)H-Index: 20
#2Mark E. Meyerhoff (UM: University of Michigan)H-Index: 60
Last. Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 29
view all 3 authors...
Abstract A dual functional polyurethane (PU) film that mimics aspects of blood vessel inner surfaces by combining surface texturing and nitric oxide (NO) release was fabricated through a soft lithography two-stage replication process. The fabrication of submicron textures on the polymer surface was followed by solvent impregnation with the NO donor, S-nitroso-N-acetylpenicillamine (SNAP). An in vitro plasma coagulation assay showed that the biomimetic surface significantly increased the plasma c...
8 CitationsSource
#1Li-Chong XuH-Index: 20
#2Chen ChenH-Index: 11
Last. Christopher A. SiedleckiH-Index: 29
view all 4 authors...
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