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Christopher A. Siedlecki
Pennsylvania State University
96Publications
28H-index
2,799Citations
Publications 95
Newest
#1Maud Gorbet (UW: University of Waterloo)H-Index: 12
#2Claudia SperlingH-Index: 15
Last.Michael V. Sefton (U of T: University of Toronto)H-Index: 41
view all 6 authors...
Abstract Following protein adsorption/activation which is the first step after the contact of material surfaces and whole blood (part 2), fibrinogen is converted to fibrin and platelets become activated and assembled in the form of a thrombus. This thrombus formation is the key feature that needs to be minimized in the creation of materials with low thrombogenicity. Further aspects of blood compatibility that are important on their own are complement and leukocyte activation which are also impor...
1 CitationsSource
#1Maud GorbetH-Index: 12
#2Claudia SperlingH-Index: 15
Last.Michael V. SeftonH-Index: 41
view all 6 authors...
#1Qilong Feng (WVU: West Virginia University)H-Index: 1
#2Christian J. Stork (WVU: West Virginia University)H-Index: 1
Last.Pingnian He (WVU: West Virginia University)H-Index: 19
view all 14 authors...
1 CitationsSource
#1Choon-Sik Jhun (PSU: Pennsylvania State University)H-Index: 7
#2Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 28
Last.Gerson Rosenberg (PSU: Pennsylvania State University)H-Index: 23
view all 10 authors...
Source
#1Li-Chong XuH-Index: 18
#2Chen ChenH-Index: 11
Last.Christopher A. SiedleckiH-Index: 28
view all 4 authors...
#1Li-Chong Xu (PSU: Pennsylvania State University)H-Index: 18
#2Mark E. Meyerhoff (UM: University of Michigan)H-Index: 59
Last.Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 28
view all 3 authors...
Abstract A dual functional polyurethane (PU) film that mimics aspects of blood vessel inner surfaces by combining surface texturing and nitric oxide (NO) release was fabricated through a soft lithography two-stage replication process. The fabrication of submicron textures on the polymer surface was followed by solvent impregnation with the NO donor, S-nitroso-N-acetylpenicillamine (SNAP). An in vitro plasma coagulation assay showed that the biomimetic surface significantly increased the plasma c...
3 CitationsSource
#1Gerson Rosenberg (PSU: Pennsylvania State University)H-Index: 23
#2Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 28
Last.William S. Pierce (PSU: Pennsylvania State University)H-Index: 30
view all 7 authors...
1 CitationsSource
#1Feng Gao (PSU: Pennsylvania State University)H-Index: 1
#2Brandon P. Lucke-Wold (WVU: West Virginia University)H-Index: 17
Last.Pingnian He (PSU: Pennsylvania State University)H-Index: 19
view all 13 authors...
Nitric oxide (NO) is a known anti-adhesive molecule that prevents platelet aggregation and leukocyte adhesion to endothelial cells (ECs). The mechanism has been attributed to its role in the regulation of adhesion molecules on leukocytes and the adhesive properties of platelets. Our previous study conducted in rat venules found that reduction of EC basal NO synthesis caused EC ICAM-1-mediated firm adhesion of leukocytes within 10-30 minutes. This quick response occurred in the absence of alterat...
1 CitationsSource
#1Y. Yan (PSU: Pennsylvania State University)H-Index: 1
#2Li-Chong Xu (PSU: Pennsylvania State University)H-Index: 18
Last.Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 28
view all 4 authors...
Abstract It is well known that the biomaterial surfaces that comprise biomedical devices will initiate blood coagulation. This can occur through the adhesion and activation of platelets, but also through the activation of the proteins of the intrinsic coagulation cascade. Nominally, this involves activation of the zymogen FXII (Hageman Factor) which in turn activates FXI, prekallikrein and high-molecular-weight kininogen to form an activation complex. The end result of this sequence of zymogen/e...
1 CitationsSource
#1Li-Chong Xu (PSU: Pennsylvania State University)H-Index: 18
#2Zhongjing Li (PSU: Pennsylvania State University)H-Index: 11
Last.Christopher A. Siedlecki (PSU: Pennsylvania State University)H-Index: 28
view all 6 authors...
Abstract A new poly[bis(octafluoropentoxy) phosphazene] (OFP) was synthesized for the purpose of blood contacting medical devices. OFP was further either developed into crosslinkable polyphosphazene (X-OFP) or blended with polyurethane (PU) as the mixture (OFP/PU) for improvement of mechanical property of polyphosphazene polymers. All the materials were fabricated as smooth films or further textured with submicron pillars for the assay of antimicrobial and antithrombotic properties. Results show...
3 CitationsSource
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