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Flavia Agata Cimini
Sapienza University of Rome
EndocrinologyType 2 diabetesFatty liverDiabetes mellitusMedicine
27Publications
7H-index
165Citations
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Publications 27
Newest
Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease
1 CitationsSource
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2G. Ciccarelli (Sapienza University of Rome)H-Index: 1
Last. Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 13 authors...
Abstract Background Dipeptidyl peptidase 4 (DPP4) is a key enzyme involved in the regulation of the incretin system exerted by cleaving the glucagon-like peptide 1 (GLP-1); the blockage of DPP4, exerted by the antidiabetic agents DPP4-inhibitors (DPP4-I), results in greater GLP-1 concentration and improved glycaemic control. DPP4 acts also as a pro-inflammatory molecule and mediates vascular damage in experimental models. The relationship between DPP4 activity and endothelial function in diabete...
Source
#1Flavia Agata Cimini (Sapienza University of Rome)H-Index: 7
#2Andrea Arena (Sapienza University of Rome)H-Index: 13
Last. Eugenio Barone (Sapienza University of Rome)H-Index: 28
view all 18 authors...
Abstract Biliverdin reductase-A (BVR-A) is a serine/threonine/tyrosine kinase involved in the regulation of insulin signaling. In vitro studies have demonstrated that BVR-A is a substrate of the insulin receptor and regulates IRS1 by avoiding its aberrant activation, and in animal model of obesity the loss of hepatic BVR-A has been associated with glucose/insulin alterations and fatty liver disease. However, no studies exist in humans. Here, we evaluated BVR-A expression levels and activation in...
6 CitationsSource
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2Flavia Agata Cimini (Sapienza University of Rome)H-Index: 7
Last. Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 5 authors...
Adipose tissue (AT) is one of the largest endocrine organs contributing to metabolic homeostasis. The functional pleiotropism of AT depends on its ability to secrete a large number of hormones, cytokines, extracellular matrix proteins and growth factors, all influencing many local and systemic physiological and pathophysiological processes. In condition of chronic positive energy balance, adipocyte expansion, hypoxia, apoptosis and stress all lead to AT inflammation and dysfunction, and it has b...
1 CitationsSource
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2Valentina Ceccarelli (Sapienza University of Rome)H-Index: 5
Last. Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 9 authors...
Purpose Osteopontin (OPN), osteoprotegerin (OPG) and osteocalcin (OC) are matrix glycoproteins which mediate bone mineralization; moreover, their effects on glucose/insulin homeostasis have recently been demonstrated. Higher circulating OPN and OPG levels have been associated with the presence of insulin resistance, atherosclerosis and coronary heart disease. No data are available on contextual changes of these markers in type 2 diabetes mellitus (T2DM). Therefore, aims of this study were to eva...
2 CitationsSource
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2Sofia Enhörning (Lund University)H-Index: 9
Last. Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 10 authors...
Introduction Copeptin is the stable surrogate marker of vasopressin (VP), which is released in response to elevated plasma osmolality or low blood pressure. Elevated plasma copeptin levels are associated with higher risk of insulin resistance-related disorders, such as type 2 diabetes (T2DM), metabolic syndrome (MS), and cardiovascular disease, and experimental reduction of circulating VP levels is shown to significantly decrease hepatic fat content in obese rats, independently from body adiposi...
2 CitationsSource
Source
#1Flavia Agata Cimini (Sapienza University of Rome)H-Index: 7
#2Donatella D’Eliseo (Tuscia University)H-Index: 2
Last. Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 6 authors...
Abstract In metabolic diseases, like type 2 diabetes (T2D), adipose tissue (AT) is infiltrated by macrophages and other leukocytes – which secrete many bioactive peptides leading to local and systemic low-grade chronic inflammation – and undergoes remodeling and aberrant fibrosis. Granzyme B (GrB) is a serine protease produced by some leukocytes, including cytotoxic lymphocytes and macrophages. It exerts both intracellular apoptotic function and extracellular functions, leading to tissue injury,...
2 CitationsSource
#1Laura Bertoccini (Sapienza University of Rome)H-Index: 7
#2Federica Sentinelli (Sapienza University of Rome)H-Index: 17
Last. Marco Giorgio Baroni (Sapienza University of Rome)H-Index: 30
view all 10 authors...
Source
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2Flavia Agata Cimini (Sapienza University of Rome)H-Index: 7
Last. Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 8 authors...
BACKGROUND:Procollagen-III peptide (PIIINP) is a marker of fibrosis associated with increased cardiometabolic risk and progression of chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) and steatohepatitis; its association with type 2 diabetes mellitus (T2DM) has not been elucidated yet. The aim of this study was to investigate the relationship among circulating PIIINP levels, metabolic traits, and body fat distribution in subjects with T2DM with or without NAFLD. METHODS:Dat...
1 CitationsSource
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