Sarah G. Staedke
University of London
Public healthImmunologyAmodiaquineMalariaMedicine
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Publications 155
#1Alex K. Musiime (UPR-RP: UPRRP College of Natural Sciences)H-Index: 3
#2David L. Smith (UW: University of Washington)H-Index: 83
Last. A. M. Akol (UPR-RP: UPRRP College of Natural Sciences)H-Index: 8
view all 15 authors...
Over the last two decades, there has been remarkable progress in malaria control in sub-Saharan Africa, due mainly to the massive deployment of long-lasting insecticidal nets and indoor residual spraying. Despite these gains, it is clear that in many situations, additional interventions are needed to further reduce malaria transmission. The World Health Organization (WHO) has promoted the Integrated Vector Management (IVM) approach through its Global Vector Control Response 2017–2030. However, p...
#1Sarah G. Staedke (Lond: University of London)H-Index: 40
#2Samuel GonahasaH-Index: 5
Last. Simon P. KigoziH-Index: 6
view all 13 authors...
Summary Background Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda's national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors. Methods 104 health sub-districts, from 48 districts in Uganda, were randomly assigned t...
1 CitationsSource
#1Simon P. Kigozi (Lond: University of London)H-Index: 6
#2Emanuele Giorgi (Lancaster University)H-Index: 11
Last. Sarah G. Staedke (Lond: University of London)H-Index: 40
view all 12 authors...
Global malaria burden is reducing with effective control interventions, and surveillance is vital to maintain progress. Health management information system (HMIS) data provide a powerful surveillance tool; however, its estimates of burden need to be better understood for effectiveness. We aimed to investigate the relationship between HMIS and cohort incidence rates and identify sources of bias in HMIS-based incidence. Malaria incidence was estimated using HMIS data from 15 health facilities in ...
#1Inke Nadia D Lubis (Lond: University of London)
#2Hendri Wijaya (University of North Sumatra)H-Index: 1
Last. Colin J. Sutherland (Lond: University of London)H-Index: 50
view all 7 authors...
Background: We assessed the efficacy of artemisinin-based combination therapies for treatment of uncomplicated falciparum malaria, with or without co-infecting Plasmodium spp., in Sumatera, Indonesia. Methods: Febrile patients aged >6 months with uncomplicated P. falciparum were randomized to receive dihydroartemisinin-piperaquine or artemether-lumefantrine, plus single-dose primaquine, and were followed for 42 days. Mixed Plasmodium infections were included; P. vivax infections received 14 days...
#1Simon P Kigozi (Lond: University of London)
#1Simon P. Kigozi (Lond: University of London)H-Index: 6
Last. Damian RutazaanaH-Index: 1
view all 17 authors...
BACKGROUND: Malaria control using long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) has been associated with reduced transmission throughout Africa. However, the impact of transmission reduction on the age distribution of malaria cases remains unclear. METHODS: Over a 10-year period (January 2009 to July 2018), outpatient surveillance data from four health facilities in Uganda were used to estimate the impact of control interventions on temporal changes in ...
#1Michael T. Bretscher (Imperial College London)H-Index: 12
#2Prabin Dahal (University of Oxford)H-Index: 8
Last. Emmanuelle EspiéH-Index: 3
view all 29 authors...
BACKGROUND: The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ), with amodiaquine being also widely used as part of seasonal malaria chemoprevention programs combined with sulfadoxine-pyrimethamine. While artemisinin derivatives have a short half-life, lumefantrine and amodiaquine may give rise to differing durations of post-treatment prophylaxis, an important addition...
#1Shennae O'Boyle (Lond: University of London)H-Index: 1
Last. Obinna Onwujekwe (UNN: University of Nigeria, Nsukka)H-Index: 33
view all 14 authors...
Background There has been a successful push towards parasitological diagnosis of malaria in Africa, mainly with rapid diagnostic tests (mRDTs), which has reduced over-prescribing of artemisinin-based combination therapies (ACT) to malaria test-negative patients. The effect on prescribing for test-positive patients has received much less attention. Malaria infection in endemic Africa is often most dangerous for young children and those in low-transmission settings. This study examined non-prescri...
#1Kate Zinszer (UdeM: Université de Montréal)H-Index: 5
#2Katia Charland (UdeM: Université de Montréal)H-Index: 7
Last. Grant Dorsey (UCSF: University of California, San Francisco)H-Index: 58
view all 15 authors...
BACKGROUND: Indoor residual spraying is widely used as a vector control measure although there are conflicting findings of its effectiveness in reducing malaria incidence. The objective of this study was to estimate the effect of multiple indoor residual spraying (IRS) rounds on malaria incidence and haemoglobin levels in a cohort of children in rural southeastern Uganda. METHODS: The study was based upon a dynamic cohort of children aged 0.5-10 years enrolled from August 2011 to June 2017 in Na...
#1Alex K. Musiime (UPR-RP: UPRRP College of Natural Sciences)H-Index: 3
#2David L. Smith (UW: University of Washington)H-Index: 83
Last. James P. Egonyu (UPR-RP: UPRRP College of Natural Sciences)H-Index: 1
view all 13 authors...
Long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) are widely recommended for the prevention of malaria in endemic regions. Data from human landing catches provide information on the impact of vector control on vector populations. Here, malaria transmission indoors and outdoors, before and after mass deployment of LLINs and IRS in Uganda was compared. The study took place in Tororo district, a historically high transmission area where universal LLIN distribu...
3 CitationsSource
#1Rebecca Thomson (Lond: University of London)H-Index: 6
#2Khalid B. Beshir (Lond: University of London)H-Index: 13
Last. Heidi Hopkins (Lond: University of London)H-Index: 14
view all 10 authors...
Background Malaria rapid diagnostic tests (mRDT) that target histidine-rich protein 2 (HRP2) are important tools for Plasmodium falciparum diagnosis. Parasites with pfhrp2/3 gene deletions threaten the use of these mRDTs, and have been reported in Africa, Asia, and South America. We studied blood samples from three African countries to determine if these gene deletions were present. Methods We analysed 911 dried blood spots from Ghana (165), Tanzania (176) and Uganda (570). P.falciparum infectio...
1 CitationsSource