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George Davey-Smith
University of Bristol
2,675Publications
177H-index
164kCitations
Publications 2675
Newest
#1David L. Duffy (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 65
#2Gu Zhu (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 39
Last.Seyhan Yazar (UWA: University of Western Australia)H-Index: 15
view all 10 authors...
The original version of this Article contained errors in the spelling of the authors Fan Liu and M. Arfan Ikram, which were incorrectly given as Fan Lui and Arfan M. Ikram. In addition, the original version of this Article also contained errors in the author affiliations which are detailed in the associated Publisher Correction.
#1Simon Haworth (UoB: University of Bristol)H-Index: 4
#2Chin Yang Shapland (MPG: Max Planck Society)H-Index: 3
Last.Tarunveer S. Ahluwalia (UCPH: University of Copenhagen)H-Index: 4
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Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include both age-specific genetic factors and low-frequency genetic variation. Here, we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic determin...
#1Simon Haworth (Medical Research Council)H-Index: 4
#2Ruth Mitchell (Medical Research Council)H-Index: 4
Last.Lavinia Paternoster (Medical Research Council)H-Index: 39
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Large studies use genotype data to discover genetic contributions to complex traits and infer relationships between those traits. Co-incident geographical variation in genotypes and health traits can bias these analyses. Here we show that single genetic variants and genetic scores composed of multiple variants are associated with birth location within UK Biobank and that geographic structure in genotype data cannot be accounted for using routine adjustment for study centre and principal componen...
#1Yongjie Yang (BCM: Baylor College of Medicine)H-Index: 8
#2Agatha A. van der Klaauw (University of Cambridge)H-Index: 15
Last.Antentor Othrell Hinton (BCM: Baylor College of Medicine)H-Index: 8
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Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozy...
#1Ellen Verhoef (MPG: Max Planck Society)H-Index: 2
#2Ditte Demontis (Lundbeck)H-Index: 22
Last.George Davey-Smith (UoB: University of Bristol)H-Index: 177
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Interpreting polygenic overlap between ADHD and both literacy-related and language-related impairments is challenging as genetic associations might be influenced by indirectly shared genetic factors. Here, we investigate genetic overlap between polygenic ADHD risk and multiple literacy-related and/or language-related abilities (LRAs), as assessed in UK children (N ≤ 5919), accounting for genetically predictable educational attainment (EA). Genome-wide summary statistics on clinical ADHD and year...
#1Alexandra HavdahlH-Index: 1
#2Ruth Mitchell (UoB: University of Bristol)H-Index: 4
Last.George Davey-Smith (UoB: University of Bristol)H-Index: 177
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Self-reported tiredness or low energy, often referred to as fatigue, has been linked to low levels of circulating 25-hydroxyvitamin D (25OHD), a biomarker of vitamin D status. Although it is uncertain if the association is causal, fatigue is a common indication for testing, and correcting, low 25OHD-levels. We used two-sample Mendelian randomization to test for genetic evidence of a causal association between low 25OHD-levels and fatigue. Genetic-25OHD associations were estimated from the larges...
#1Lauren E. Mokry (McGill University)H-Index: 7
#2Sirui Zhou (McGill University)H-Index: 7
Last.Philippe Sanseau (GSK: GlaxoSmithKline)H-Index: 21
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Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the interleukin-18 (IL18) signaling pathway, and pharmacologic inhibition of IL18 has been shown to reverse this enterocolitis, we undertook a Mendelian randomization study to test the causal effect of elevated IL18 levels on inflammatory bowel disease s...
#1Kurt Taylor (UoB: University of Bristol)H-Index: 1
#2George Davey-Smith (NIHR: National Institute for Health Research)H-Index: 177
Last.Tom G. Richardson (UoB: University of Bristol)H-Index: 6
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The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analysis pipeline that integrates tissue-specific gene expression, Mendelian randomization and multiple-trait colocalization to develop functional mechanistic insight into the causal pathway from a genetic variant to a complex trait. We undertook an expression quantitative trait loci-wide association study to uncover...
#1Leanne K. KüpersH-Index: 9
#2Claire Monnereau (EUR: Erasmus University Rotterdam)H-Index: 6
Last.Darina Czamara (MPG: Max Planck Society)H-Index: 26
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Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10−7). In additi...
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