George Davey-Smith
University of Bristol
Publications 2379
Published on Feb 1, 2019in International Journal of Epidemiology 8.36
Fernando Pires Hartwig12
Estimated H-index: 12
(Medical Research Council),
Neil M Davies18
Estimated H-index: 18
(University of Bristol)
+ 24 AuthorsAyesha Sajjad7
Estimated H-index: 7
Background: Accumulating evidence suggests that breastfeeding benefits children's intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, an interaction between breastfeeding and genetic variants associated with endogenous LC-PUFAs synthesis might be expected. However, the literature on this topic is controversial. Methods: We investigated this gene × environment interaction through a collaborative effort. T...
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Published on Mar 28, 2019in bioRxiv
Padraig Dixon5
Estimated H-index: 5
(University of Bristol),
William Hollingworth39
Estimated H-index: 39
(University of Bristol)
+ 2 AuthorsGeorge Davey-Smith173
Estimated H-index: 173
(University of Bristol)
Estimates of the marginal effect of measures of adiposity such as body mass index (BMI) on healthcare costs are important for the formulation and evaluation of policies targeting adverse weight profiles. Many existing estimates of this association are affected by endogeneity bias caused by simultaneity, measurement error and omitted variables. The contribution of this study is to avoid this bias by using a novel identification strategy-random germline genetic variation in an instrumental variabl...
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Published on Jan 1, 2019in Cancer Epidemiology, Biomarkers & Prevention 4.55
Charleen D. Adams1
Estimated H-index: 1
(University of Bristol),
Rebecca C Richmond19
Estimated H-index: 19
(University of Bristol)
+ 73 AuthorsRichard M. Martin99
Estimated H-index: 99
(University of Bristol)
Background: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR). Materials and Methods: The case-control portion of the study was conducted in nine UK centres with men aged 50-69 years who underwent prostate-specific antigen (PS...
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Published on Jan 3, 2019in PLOS Medicine 11.68
Mattias Johansson38
Estimated H-index: 38
Robert Carreras-Torres6
Estimated H-index: 6
+ 110 AuthorsZhining Wang66
Estimated H-index: 66
Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk in a mendelian randomization (MR) framework. This methodology limits bias due to confounding and is not affected by reverse causation. Genetic markers associated with obesity measures, blood pressure, lipids, type 2 dia...
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Published on Mar 7, 2019in Schizophrenia Bulletin 6.94
Thomas Lancaster9
Estimated H-index: 9
(Cardiff University),
Stavros L Dimitriadis1
Estimated H-index: 1
(Cardiff University)
+ 12 AuthorsGeorge Davey-Smith173
Estimated H-index: 173
(University of Bristol)
Risk profile scores (RPS) derived from genome-wide association studies (GWAS) explain a considerable amount of susceptibility for schizophrenia (SCZ). However, little is known about how common genetic risk factors for SCZ influence the structure and function of the human brain, largely due to the constraints of imaging sample sizes. In the current study, we use a novel recall-by-genotype (RbG) methodological approach, where we sample young adults from a population cohort (Avon Longitudinal Study...
3 Citations Source Cite
Published on Feb 1, 2019in Epigenomics 4.98
Laurence J. Howe3
Estimated H-index: 3
(University of Bristol),
Tom G Richardson5
Estimated H-index: 5
(University of Bristol)
+ 15 AuthorsMichael Knapp45
Estimated H-index: 45
(University of Bonn)
Aim: To determine if nsCL/P genetic risk variants influence liability to nsCL/P through gene regulation pathways, such as those involving DNA methylation. Materials and Methods: nsCL/P genetic summary data and methylation data from four studies were used in conjunction with Mendelian randomization and joint likelihood mapping to investigate potential mediation of nsCL/P genetic variants. Results and conclusion: Evidence was found at VAX1 (10q25.3), LOC146880 (17q23.3) and NTN1 (17p13.1), that li...
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Published on Jan 31, 2019in PLOS Medicine 11.68
Ashley Budu-Aggrey1
Estimated H-index: 1
(University of Bristol),
Ben Michael Brumpton8
Estimated H-index: 8
(Medical Research Council)
+ 25 AuthorsLars G. Fritsche6
Estimated H-index: 6
(Norwegian University of Science and Technology)
Background: Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis. Methods and Findings: Following a review of published epidemiological evidence of the association between obesity and psoriasis, mendelian randomization (MR) was used to test for a causal relationship with BMI. We used a genetic instrument comprising 97 single-nucleotide polymorphisms ...
1 Citations Source Cite
Published on Mar 20, 2019in Neurology 8.05
Adil Harroud1
Estimated H-index: 1
(McGill University),
John A. Morris9
Estimated H-index: 9
(McGill University)
+ 4 AuthorsJ. Brent Richards41
Estimated H-index: 41
Objective To investigate the potential for a causal effect of age at puberty on multiple sclerosis (MS) susceptibility using a mendelian randomization (MR) approach. Methods We used 372 genetic variants strongly associated with age at menarche in a genome-wide association study (GWAS) involving 329,245 women. The genetic architecture of pubertal timing across both sexes is highly correlated (genetic correlation [ r g ] = 0.75, p = 1.2 × 10 −79 ), allowing these variants to provide reliable insig...
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Published on Jan 21, 2019in Nature Communications 12.35
Simon Haworth3
Estimated H-index: 3
(University of Bristol),
Chin Yang Shapland2
Estimated H-index: 2
(Max Planck Society)
+ 32 AuthorsMartine Vrijheid43
Estimated H-index: 43
(Pompeu Fabra University)
Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include both age-specific genetic factors and low-frequency genetic variation. Here, we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic determin...
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