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George Davey-Smith
University of Bristol
2,549Publications
177H-index
164kCitations
Publications 2549
Newest
Published on Jan 31, 2019in Genome Medicine 8.90
Kurt Taylor1
Estimated H-index: 1
(University of Bristol),
George Davey-Smith177
Estimated H-index: 177
+ 2 AuthorsTom G. Richardson5
Estimated H-index: 5
(University of Bristol)
Background The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analysis pipeline that integrates tissue-specific gene expression, Mendelian randomization and multiple-trait colocalization to develop functional mechanistic insight into the causal pathway from a genetic variant to a complex trait.
1 Citations Source Cite
Published on Jan 21, 2019in Nature Communications 12.35
Simon Haworth4
Estimated H-index: 4
(University of Bristol),
Chin Yang Shapland3
Estimated H-index: 3
(Max Planck Society)
+ 32 AuthorsMartine Vrijheid45
Estimated H-index: 45
(Pompeu Fabra University)
Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include both age-specific genetic factors and low-frequency genetic variation. Here, we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic determin...
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Published on Jan 18, 2019in Nature Communications 12.35
Simon Haworth4
Estimated H-index: 4
(Medical Research Council),
Ruth Mitchell4
Estimated H-index: 4
(Medical Research Council)
+ 10 AuthorsGeorge Davey-Smith177
Estimated H-index: 177
(Medical Research Council)
Large studies use genotype data to discover genetic contributions to complex traits and infer relationships between those traits. Co-incident geographical variation in genotypes and health traits can bias these analyses. Here we show that single genetic variants and genetic scores composed of multiple variants are associated with birth location within UK Biobank and that geographic structure in genotype data cannot be accounted for using routine adjustment for study centre and principal componen...
9 Citations Source Cite
Published on Jan 24, 2019in Translational Psychiatry 4.69
Ellen Verhoef2
Estimated H-index: 2
(Max Planck Society),
Ditte Demontis21
Estimated H-index: 21
(Lundbeck)
+ 11 AuthorsGeorge Davey-Smith177
Estimated H-index: 177
(University of Bristol)
Interpreting polygenic overlap between ADHD and both literacy-related and language-related impairments is challenging as genetic associations might be influenced by indirectly shared genetic factors. Here, we investigate genetic overlap between polygenic ADHD risk and multiple literacy-related and/or language-related abilities (LRAs), as assessed in UK children (N ≤ 5919), accounting for genetically predictable educational attainment (EA). Genome-wide summary statistics on clinical ADHD and year...
1 Citations Source Cite
Published on Feb 27, 2019in Scientific Reports 4.12
Alexandra Havdahl1
Estimated H-index: 1
,
Ruth Mitchell4
Estimated H-index: 4
(University of Bristol)
+ 1 AuthorsGeorge Davey-Smith177
Estimated H-index: 177
(University of Bristol)
Self-reported tiredness or low energy, often referred to as fatigue, has been linked to low levels of circulating 25-hydroxyvitamin D (25OHD), a biomarker of vitamin D status. Although it is uncertain if the association is causal, fatigue is a common indication for testing, and correcting, low 25OHD-levels. We used two-sample Mendelian randomization to test for genetic evidence of a causal association between low 25OHD-levels and fatigue. Genetic-25OHD associations were estimated from the larges...
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Published on Apr 23, 2019in Nature Communications 12.35
Leanne K. Küpers8
Estimated H-index: 8
,
Claire Monnereau6
Estimated H-index: 6
(Erasmus University Rotterdam)
+ 124 AuthorsDarina Czamara26
Estimated H-index: 26
(Max Planck Society)
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10−7). In additi...
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Published on Jan 3, 2019in Nature Communications 12.35
Alex Morris82
Estimated H-index: 82
(University of Oxford),
Thu H. Le21
Estimated H-index: 21
(University of Virginia)
+ 69 AuthorsGirish N. Nadkarni18
Estimated H-index: 18
(Icahn School of Medicine at Mount Sinai)
Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD, in 312,468 individuals of diverse ancestry. We identify 127 distinct association signals with homogeneous effects on eGFR across ancestries and enrichment in genomic annotations including kidney-specific histone modifications. ...
3 Citations Source Cite
Published on Jul 1, 2019in Atherosclerosis 4.47
Mie Balling , Anne Langsted15
Estimated H-index: 15
+ 3 AuthorsBørge G. Nordestgaard114
Estimated H-index: 114
BACKGROUND AND AIMS:Increased concentrations of calculated remnant cholesterol in triglyceride-rich lipoproteins are observationally and genetically, causally associated with increased risk of ischemic heart disease; however, when measured directly, the fraction of plasma cholesterol present in remnant particles is unclear. We tested the hypothesis that a major fraction of plasma cholesterol is present in remnant lipoproteins in individuals in the general population. METHODS:We examined 9293 ind...
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Published on May 15, 2019in bioRxiv
Richard Howey12
Estimated H-index: 12
(Newcastle University),
So-Youn Shin28
Estimated H-index: 28
(University of Bristol)
+ 2 AuthorsHeather J. Cordell57
Estimated H-index: 57
(Newcastle University)
Mendelian randomization (MR) is an increasingly popular causal inference tool used in genetic epidemiology. But it can have limitations for evaluating simultaneous causal relationships in complex data sets that include, for example, multiple genetic predictors and multiple potential risk factors associated with the same genetic variant. Here we use real and simulated data to investigate Bayesian network analysis (BN) as an alternative approach. A Bayesian network describes the conditional depend...
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Padraig Dixon6
Estimated H-index: 6
,
George Davey-Smith177
Estimated H-index: 177
,
William Hollingworth42
Estimated H-index: 42
Background High adiposity is associated with higher risks for a variety of adverse health outcomes, including higher rates of age-adjusted mortality and increased morbidity. This has important implications for the management of healthcare systems, since the endocrinal, cardiometabolic and other changes associated with increased adiposity may be associated with substantial healthcare costs.
1 Citations Source Cite
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