Stéphanie P. Häuselmann
University of Basel
Molecular biologyCardiologyNADPH oxidaseMedicineProtein kinase B
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Publications 9
#1Friederike Schulze (University of Basel)H-Index: 4
#2Josua Wehner (University of Basel)
Last. Sophia J. Wiedemann (University of Basel)
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Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the role of inflammation in GDM. We established a mouse model for GDM on the basis of its two major risk factors, obesity and aging. In these GDM mice, we observed increased Interleukin-1β (IL-1β) expression in the uterus and the placenta along with elev...
#1Marianne Böni-Schnetzler (University of Basel)H-Index: 18
#2Stéphanie P. Häuselmann (University of Basel)H-Index: 5
Last. Marc Y. Donath (University of Basel)H-Index: 60
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Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
10 CitationsSource
#1Otmar Pfister (University of Basel)H-Index: 18
#2Vera Lorenz (University of Basel)H-Index: 4
Last. Gabriela M. Kuster (University of Basel)H-Index: 13
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Objectives The goal of this study was to define the role of FMS-like tyrosine kinase 3 (FLT3) in the heart. Background FLT3 is a prominent target of receptor tyrosine kinase inhibitors (TKIs) used for anticancer therapy. TKIs can cause cardiomyopathy but understanding of the mechanisms is incomplete, partly because the roles of specific TKI target receptors in the heart are still obscure. Methods Myocardial infarction was induced in mice by permanent ligation of the left anterior descending coro...
11 CitationsSource
Aims The highly expressed cell adhesion receptor CD29 (β1-integrin) is essential for cardiomyocyte growth and survival, and its loss of function causes severe heart disease. However, CD29-induced signalling in cardiomyocytes is ill defined and may involve reactive oxygen species (ROS). A decisive source of cardiac ROS is the abundant NADPH oxidase (NOX) isoform NOX2. Because understanding of NOX-derived ROS in the heart is still poor, we sought to test the role of ROS and NOX in CD29-induced sur...
18 CitationsSource
#1Otmar PfisterH-Index: 18
#2Vera LorenzH-Index: 4
Last. Gabriela M. KusterH-Index: 13
view all 6 authors...
echocardiographic evaluation and health status questionnaire (Kansas City Cardiomyopathy Questionnaire [KCCQ]). FeNO was determined at rest and immediately (!2 minutes) after symptom-limited cardiopulmonary stress testing using modified Naughton protocol. Results: In our study cohort (mean age 53 613 years, 76% male, median LVEF 31%, interquartile range [IQR]: 25 to 40), the rest and peak exercise median FeNO were 17 ppb [IQR: 14 to 22] and 20 ppb [IQR: 17 to 31], respectively. There was a stron...
0.866 (!0.000) 0.846 (!0.000) 0.881 (!0.000) miR-21 0.700 (!0.002) 0.659 (0.059) 0.730 (0.002) miR-126 0.672 (!0.007) 0.645 (0.083) 0.692 (0.011) miR-133a 0.695 (!0.002) 0.734 (0.005) 0.666 (0.025) miR-208 0.666 (!0.008) 0.682 (0.024) 0.652 (0.046) Let7a 0.646 (!0.020) 0.576 (0.348) 0.706 (0.007) All data expressed as area under the curve(AUC), c statistic; (p value). Conclusions: Several peripheral blood miRNAs are significantly disregulated in ID and IS patients when compared to normal control...
#1Stéphanie P. Häuselmann (University of Basel)H-Index: 5
#2Berit I. Rosc-Schlüter (University of Basel)H-Index: 3
Last. Gabriela M. Kuster (University of Basel)H-Index: 13
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beta(1)-Integrin mediates cardiomyocyte growth and survival and its proper regulation is essential for the structural and functional integrity of the heart. beta(1)-Integrin expression is enhanced in hypertrophy, but the mechanism and significance of its up-regulation are unknown. Because reactive oxygen species (ROS) are important mediators of myocardial remodeling we examined their role in regulated beta(1)-integrin expression. Hypertrophy was induced in neonatal cardiomyocytes by endothelin-1...
13 CitationsSource
Last. Gabriela M. KusterH-Index: 13
view all 6 authors...
Abstract The totality of functional cardiomyocytes and an intact cardiac progenitor cell pool are key players in the myocardial cell homeostasis. Perturbation of either one may compromise the structural and functional integrity of the heart and lead to heart failure. Reactive oxygen/nitrogen species (ROS/RNS) are important regulators of cardiomyocyte viability; more recently, the interrelation between ROS and progenitor cell behavior and fate has moved into the spotlight. Increasing evidence sug...
9 CitationsSource