Christian Hassager
Copenhagen University Hospital
CardiologyIntensive care medicineHeart failureDiabetes mellitusMedicine
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Publications 531
#1Lauge Østergaard (Rigshospitalet)
#2Anders Dahl (Bispebjerg Hospital)H-Index: 6
Last. Emil L. Fosbøl (Rigshospitalet)H-Index: 37
view all 13 authors...
Background Significant valve regurgitation is common in patients surviving native valve infective endocarditis (IE), however the associated risk of heart failure (HF) subsequent to hospital discharge after IE is sparsely described. Methods We linked data from the East Danish Endocarditis Registry with administrative registries from 2002 to 2016 and included patients treated medically for IE who were discharged alive. Left-sided valve regurgitation was assessed by echocardiography at IE discharge...
#1Matilde Winther-Jensen (Frederiksberg Hospital)H-Index: 10
#2Mia N. Christiansen (Copenhagen University Hospital)H-Index: 4
Last. Charlotte Andersson (UCPH: University of Copenhagen)H-Index: 23
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Abstract Background The general cardiovascular health has improved throughout the last few decades for middle-aged and older individuals, but the incidence of several cardiovascular diseases is reported to increase in younger people. We aimed to assess the age-specific incidence and mortality rates associated with out-of-hospital-cardiac-arrest (OHCA) between 2002 and 2014. Methods We used the Danish Cardiac Arrest Register to identify patients with OHCA of presumed cardiac etiology. We calculat...
Abstract Background Cardiac arrest may be the first manifestation in the majority of inherited cardiac diseases. International guidelines recommend screening of relatives of Sudden Cardiac Arrest (SCA) survivors if an inherited cardiac disorder is suspected. Objective To assess the prevalence and spectrum of inherited cardiac diseases and the long-term outcome in a consecutive cohort of non-ischemic SCA survivors (probands) and their relatives. Methods This retrospective study consecutively incl...
#1Birgit Debrabant (University of Southern Denmark)H-Index: 8
#2Ulrich Halekoh (University of Southern Denmark)H-Index: 17
Last. Lars Melholt Rasmussen (OUH: Odense University Hospital)H-Index: 41
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AIM Acute myocardial infarction (AMI) remains a major cause of mortality and morbidity, and cardiogenic shock (CS) a major cause of hospital mortality after AMI. Especially for ST elevation myocardial infarction (STEMI) patients, fast intervention is essential.Few proteins have proven clinically applicable for AMI. Most proposed biomarkers are based on a priori hypothesis driven studies of single proteins, not enabling identification of novel candidates. For clinical use, the ability to predict ...
#1Johannes Grand (Copenhagen University Hospital)H-Index: 3
#2Christian Hassager (Copenhagen University Hospital)H-Index: 60
Last. Jesper Kjaergaard (Copenhagen University Hospital)H-Index: 31
view all 8 authors...
Targeted temperature management (TTM) exerts substantial impact on hemodynamic function in out-of-hospital cardiac arrest (OHCA) patients. Whole-body oxygen consumption (VO2) and delivery (DO2) have not previously been investigated in a clinical setting during TTM at different levels of temperature after OHCA. A substudy of 151 patients randomized at a single center in the TTM-trial, where patients were randomly assigned TTM at 33°C (TTM33) or 36°C (TTM36) for 24 hours. We calculated VO2 accordi...
#2Niklas Nielsen (Lund University)H-Index: 33
Last. Michael A. KuiperH-Index: 40
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Outcome prognostication after cardiac arrest (CA) is challenging. Current multimodal prediction approaches would benefit from new biomarkers. MicroRNAs constitute a novel class of disease markers and circulating levels of brain-enriched ones have been associated with outcome after CA. To determine whether these levels reflect the extent of brain damage in CA patients, we assessed their correlation with neuron-specific enolase (NSE), a marker of brain damage. Blood samples taken 48 h after return...
#1Johannes Grand (Copenhagen University Hospital)H-Index: 3
#2Christian Hassager (Copenhagen University Hospital)H-Index: 60
Last. Jens Nee (Charité)H-Index: 11
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Background Comatose patients admitted after out-of-hospital cardiac arrest frequently experience haemodynamic instability and anoxic brain injury. Targeted temperature management is used for neurop...
#1Marion Moseby-Knappe (Lund University)H-Index: 2
#2Erik Westhall (Lund University)H-Index: 12
Last. Janneke HornH-Index: 35
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PURPOSE To assess the performance of a 4-step algorithm for neurological prognostication after cardiac arrest recommended by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM). METHODS Retrospective descriptive analysis with data from the Target Temperature Management (TTM) Trial. Associations between predicted and actual neurological outcome were investigated for each step of the algorithm with results from clinical neurological examinations, ne...
#1Sebastian Wiberg (Copenhagen University Hospital)H-Index: 8
#2A.G. Vedel (Copenhagen University Hospital)
Last. Jens-Christian Nilsson (Copenhagen University Hospital)H-Index: 1
view all 9 authors...
Abstract Objectives To assess the association between total volume and number of gaseous microemboli (GME) in the cardiopulmonary bypass (CPB) circuit and the occurrence of new postoperative cerebral infarcts and postoperative cognitive dysfunction (POCD) in patients undergoing cardiac surgery. Design Pre-defined sub-analyses of the randomized controlled Perfusion Pressure Cerebral Infarcts (PPCI) trial. Setting Primary heart center in a university hospital. Participants A total of 143 adult pat...
1 CitationsSource
#1Sebastian Wiberg (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 8
#2Mathias J. Holmberg (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 10
Last. Anne V. GrossestreuerH-Index: 15
view all 20 authors...
BACKGROUND: While survival after in-hospital cardiac arrest (IHCA) has improved in recent years, it remains unknown whether this trend primarily applies to younger IHCA victims. The aim of this study was to assess trends in survival to hospital discharge after adult IHCA across age groups from 2000 to 2016. METHODS: This is an observational study of IHCA patients included in the Get With The Guidelines(R)-Resuscitation registry between 2000 and 2016. The primary outcome was survival to hospital ...
1 CitationsSource