Match!
Ursula Klingmüller
German Cancer Research Center
144Publications
38H-index
5,763Citations
Publications 144
Newest
Published on Jan 1, 2019
Marcus Rosenblatt2
Estimated H-index: 2
(University of Freiburg),
M Teusel (DKFZ: German Cancer Research Center)+ 2 AuthorsJ. Timmer (University of Freiburg)
Published on Jan 1, 2019
Seddik Hammad18
Estimated H-index: 18
(SVU: South Valley University),
Uta Dahmen24
Estimated H-index: 24
+ 4 AuthorsSteven Dooley45
Estimated H-index: 45
(Heidelberg University)
Published on Dec 1, 2018in Scientific Reports4.01
D. Dvornikov1
Estimated H-index: 1
(DKFZ: German Cancer Research Center),
Martin Schneider17
Estimated H-index: 17
(University Hospital Heidelberg)
+ 14 AuthorsHendrik Dienemann43
Estimated H-index: 43
(University Hospital Heidelberg)
In lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined phenotypic and transcriptome-wide studies and showed that the stimulation of the LUSC cell line SK-MES1 with TGFβ results in an increase of migratory invasive properties. The analysis of the dynamics of gene expression by next-generation sequencing revealed that TGFβ stimulation orchestrates ...
Published on Dec 1, 2018
Angela Oppelt1
Estimated H-index: 1
(DKFZ: German Cancer Research Center),
Daniel Kaschek9
Estimated H-index: 9
(University of Freiburg)
+ 19 AuthorsMara Meub1
Estimated H-index: 1
(Goethe University Frankfurt)
Drug-induced liver injury (DILI) has become a major problem for patients and for clinicians, academics and the pharmaceutical industry. To date, existing hepatotoxicity test systems are only poorly predictive and the underlying mechanisms are still unclear. One of the factors known to amplify hepatotoxicity is the tumor necrosis factor alpha (TNFα), especially due to its synergy with commonly used drugs such as diclofenac. However, the exact mechanism of how diclofenac in combination with TNFα i...
Published on Dec 1, 2018in Cell discovery
Svitlana Melnik3
Estimated H-index: 3
(DKFZ: German Cancer Research Center),
Dmytro Dvornikov1
Estimated H-index: 1
(DKFZ: German Cancer Research Center)
+ 11 AuthorsAngela Risch41
Estimated H-index: 41
Use of the diabetes type II drug Metformin is associated with a moderately lowered risk of cancer incidence in numerous tumor entities. Studying the molecular changes associated with the tumor-suppressive action of Metformin we found that the oncogene SOX4, which is upregulated in solid tumors and associated with poor prognosis, was induced by Wnt/β-catenin signaling and blocked by Metformin. Wnt signaling inhibition by Metformin was surprisingly specific for cancer cells. Unraveling the underly...
Published on Sep 15, 2018in European Respiratory Journal11.81
Dominik Leitz2
Estimated H-index: 2
,
Julia Duerr11
Estimated H-index: 11
+ 8 AuthorsUrsula Klingmüller38
Estimated H-index: 38
Published on Dec 1, 2017in BMC Bioinformatics2.51
Marco Albrecht1
Estimated H-index: 1
(University of Luxembourg),
Damian Stichel10
Estimated H-index: 10
(Heidelberg University)
+ 6 AuthorsFranziska Matthäus2
Estimated H-index: 2
(Goethe University Frankfurt)
Background The analysis of microarray time series promises a deeper insight into the dynamics of the cellular response following stimulation. A common observation in this type of data is that some genes respond with quick, transient dynamics, while other genes change their expression slowly over time. The existing methods for detecting significant expression dynamics often fail when the expression dynamics show a large heterogeneity. Moreover, these methods often cannot cope with irregular and s...
Published on Dec 1, 2017in Cell systems8.64
Philippe Lucarelli4
Estimated H-index: 4
(DKFZ: German Cancer Research Center),
Marcel Schilling13
Estimated H-index: 13
(DKFZ: German Cancer Research Center)
+ 18 AuthorsMarkus Stepath3
Estimated H-index: 3
(DKFZ: German Cancer Research Center)
Summary Upon stimulation of cells with transforming growth factor β (TGF-β), Smad proteins form trimeric complexes and activate a broad spectrum of target genes. It remains unresolved which of the possible Smad complexes are formed in cellular contexts and how these contribute to gene expression. By combining quantitative mass spectrometry with a computational selection strategy, we predict and provide experimental evidence for the three most relevant Smad complexes in the mouse hepatoma cell li...
Published on Dec 1, 2017
Damian Stichel10
Estimated H-index: 10
(Heidelberg University),
Alistair M. Middleton8
Estimated H-index: 8
(Heidelberg University)
+ 4 AuthorsFranziska Matthäus10
Estimated H-index: 10
(University of Würzburg)
Collective cell migration is a common phenotype in epithelial cancers, which is associated with tumor cell metastasis and poor patient survival. However, the interplay between physiologically relevant pro-migratory stimuli and the underlying mechanical cell–cell interactions are poorly understood. We investigated the migratory behavior of different collectively migrating non-small cell lung cancer cell lines in response to motogenic growth factors (e.g. epidermal growth factor) or clinically rel...
12345678910