Ursula Klingmüller
German Cancer Research Center
Publications 146
#1Silvia Thoene (TUM: Technische Universität München)H-Index: 5
#2Tamoghna MandalH-Index: 7
Last.Michaela Feuring-BuskeH-Index: 23
view all 16 authors...
#1Richard J. WeaverH-Index: 16
#2Eric A.G. BlommeH-Index: 12
Last.B. K. Park (University of Liverpool)H-Index: 80
view all 22 authors...
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of human DILI thus remain inadequate. A systematic and concerted research effort is required to address the deficiencies in current models and to present a defined approach towards the development of new or adapted model systems for DILI prediction. This Perspective defines th...
#1Seddik Hammad (SVU: South Valley University)H-Index: 18
#2Uta DahmenH-Index: 24
Last.Steven Dooley (Heidelberg University)H-Index: 46
view all 7 authors...
#1Marcus Rosenblatt (University of Freiburg)H-Index: 3
#2M Teusel (DKFZ: German Cancer Research Center)
Last.Jens Timmer (University of Freiburg)H-Index: 69
view all 5 authors...
#1Angela Oppelt (DKFZ: German Cancer Research Center)H-Index: 1
#2Daniel Kaschek (University of Freiburg)H-Index: 10
Last.Ursula Klingmüller (DKFZ: German Cancer Research Center)H-Index: 40
view all 22 authors...
Drug-induced liver injury (DILI) has become a major problem for patients and for clinicians, academics and the pharmaceutical industry. To date, existing hepatotoxicity test systems are only poorly predictive and the underlying mechanisms are still unclear. One of the factors known to amplify hepatotoxicity is the tumor necrosis factor alpha (TNFα), especially due to its synergy with commonly used drugs such as diclofenac. However, the exact mechanism of how diclofenac in combination with TNFα i...
2 CitationsSource
#1D. Dvornikov (DKFZ: German Cancer Research Center)H-Index: 1
#2Martin Schneider (University Hospital Heidelberg)H-Index: 22
Last.Ursula Klingmüller (DKFZ: German Cancer Research Center)H-Index: 40
view all 17 authors...
In lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined phenotypic and transcriptome-wide studies and showed that the stimulation of the LUSC cell line SK-MES1 with TGFβ results in an increase of migratory invasive properties. The analysis of the dynamics of gene expression by next-generation sequencing revealed that TGFβ stimulation orchestrates ...
3 CitationsSource
#1Svitlana Melnik (DKFZ: German Cancer Research Center)H-Index: 4
#2Dmytro Dvornikov (DKFZ: German Cancer Research Center)H-Index: 1
Last.Andrey Glinka (DKFZ: German Cancer Research Center)H-Index: 4
view all 14 authors...
Use of the diabetes type II drug Metformin is associated with a moderately lowered risk of cancer incidence in numerous tumor entities. Studying the molecular changes associated with the tumor-suppressive action of Metformin we found that the oncogene SOX4, which is upregulated in solid tumors and associated with poor prognosis, was induced by Wnt/β-catenin signaling and blocked by Metformin. Wnt signaling inhibition by Metformin was surprisingly specific for cancer cells. Unraveling the underly...
1 CitationsSource
#1Dominik LeitzH-Index: 2
#2Julia DuerrH-Index: 11
Last.Marcus A. MallH-Index: 45
view all 11 authors...
#1Marco AlbrechtH-Index: 2
#2Damian Stichel (DKFZ: German Cancer Research Center)H-Index: 11
Last.Franziska Matthäus (FIAS: Frankfurt Institute for Advanced Studies)H-Index: 1
view all 9 authors...
Background The analysis of microarray time series promises a deeper insight into the dynamics of the cellular response following stimulation. A common observation in this type of data is that some genes respond with quick, transient dynamics, while other genes change their expression slowly over time. The existing methods for detecting significant expression dynamics often fail when the expression dynamics show a large heterogeneity. Moreover, these methods often cannot cope with irregular and s...
4 CitationsSource