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Giuseppe Grandaliano
University of Bari
157Publications
36H-index
4,529Citations
Publications 157
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During sepsis, the increased synthesis of circulating lipopolysaccharide (LPS)-binding protein (LBP) activates LPS/TLR4 signaling in renal resident cells, leading to acute kidney injury (AKI). Pericytes are the major source of myofibroblasts during chronic kidney disease (CKD), but their involvement in AKI is poorly understood. Here, we investigate the occurrence of pericyte-to-myofibroblast trans-differentiation (PMT) in sepsis-induced AKI. In a swine model of sepsis-induced AKI, PMT was detect...
1 CitationsSource
Aging is a physiologic/pathologic process characterized by a progressive impairment of cellular functions, supported by the alterations of several molecular pathways, leading to an increased cell susceptibility to injury. This deterioration is the primary risk factor for several major human pathologies. Numerous cellular processes, including genomic instability, telomere erosion, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, stem cell exha...
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Background: Acute kidney injury (AKI), even if followed by renal recovery, is a risk factor for the future development of chronic kidney disease (CKD) and end-stage renal disease (ESRD). In the previous years, novel insights in the pathophysiology of CKD progression suggested a causal link between AKI and CKD due to a maladaptive repair after severe and repeated injury. Summary: Several pathological mechanisms have been proposed to contribute to the progression of AKI and transition to CKD/ESRD ...
6 CitationsSource
#1Massimo PapaleH-Index: 8
#2Grazia VocinoH-Index: 4
Last.Elena RanieriH-Index: 26
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// Massimo Papale 1, 3 , Grazia Vocino 1 , Giuseppe Lucarelli 2 , Monica Rutigliano 2 , Margherita Gigante 3 , Maria Teresa Rocchetti 3 , Francesco Pesce 3 , Francesca Sanguedolce 4 , Pantaleo Bufo 4 , Michele Battaglia 2 , Giovanni Stallone 5 , Giuseppe Grandaliano 5 , Giuseppe Carrieri 6 , Loreto Gesualdo 3 and Elena Ranieri 1 1 Molecular Medicine Center, Section of Clinical Pathology, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy 2 Division of Urology, Depar...
7 CitationsSource
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#1Simona SimoneH-Index: 11
#2Fabio SallustioH-Index: 17
Last.Loreto GesualdoH-Index: 52
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