Isabelle Texier
French Alternative Energies and Atomic Energy Commission
NanoparticleChemistryIn vivoFluorescence-lifetime imaging microscopyFluorescence
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Publications 68
#1Ozgul Tezgel (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Nicholas DiStasioH-Index: 1
Last. Isabelle TexierH-Index: 19
view all 8 authors...
Abstract Achieving prolonged and localized delivery of small interfering RNA (siRNA) at a specific site is highly desirable, since siRNA therapy has become a promising strategy for many medical applications. Many different synthetic or natural biomaterials have been studied for local sustained drug delivery. Of those, collagen has received increased attention, especially for wound applications, due to its biocompatibility, safety, and hemostatic properties. Therefore, we here investigated freeze...
1 CitationsSource
#1J.-D. Vigne (University of Paris)H-Index: 1
#2Claudia CabellaH-Index: 17
Last. Dominique Le Guludec (University of Paris)H-Index: 38
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Abstract Nanostructured lipid carriers (NLC) might represent an interesting approach for the identification and targeting of rupture-prone atherosclerotic plaques. In this study, we evaluated the biodistribution, targeting ability and safety of 64Cu-fonctionalized NLC in atherosclerotic mice. 64Cu-chelating-NLC (51.8±3.1 nm diameter) with low dispersity index (0.066±0.016) were produced by high pressure homogenization at tens-of-grams scale. 24 h after injection of 64Cu-chelated particles in Apo...
Nanoparticles have been extensively studied for drug delivery and targeting to specific organs. The functionalization of the nanoparticle surface by site-specific ligands (antibodies, peptides, saccharides) can ensure efficient recognition and binding with relevant biological targets. One of the main challenges in the development of these decorated nanocarriers is the accurate quantification of the amount of ligands on the nanoparticle surface. In this study, nanostructured lipid carriers (NLC) ...
1 CitationsSource
Advanced ovarian cancer is the most lethal gynecological cancer, with a high rate of chemoresistance and relapse. Photodynamic therapy offers new prospects for ovarian cancer treatment, but current photosensitizers lack tumor specificity, resulting in low efficacy and significant side-effects. In the present work, the clinically approved photosensitizer verteporfin was encapsulated within nanostructured lipid carriers (NLC) for targeted photodynamic therapy of ovarian cancer. Cellular uptake and...
#1Laurent DevelH-Index: 15
#2Gunter AlmerH-Index: 17
Last. Isabelle TexierH-Index: 19
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Atherosclerosis is a major cardiovascular disease worldwide, that could benefit from innovative nanomedicine imaging tools and treatments. In this perspective, we here studied, by fluorescence imaging in ApoE-/- mice, the biodistribution of non-functionalized and RXP470.1-targeted nanostructured lipid carriers (NLC) loaded with DiD dye. RXP470.1 specifically binds to MMP12, a metalloprotease that is over-expressed by macrophages residing in atherosclerotic plaques. Physico-chemical characterizat...
#1Valentina Laghezza Masci (Tuscia University)H-Index: 4
#2Annarita Taddei (Tuscia University)H-Index: 6
Last. Isabelle TexierH-Index: 19
view all 9 authors...
#1Fanny CaputoH-Index: 2
#2Amandine ArnouldH-Index: 2
Last. Anne-Claude CouffinH-Index: 7
view all 8 authors...
Particle size distribution and stability are key attributes for the evaluation of the safety and efficacy profile of medical nanoparticles (Med-NPs). Measuring particle average size and particle size distribution is a challenging task which requires the combination of orthogonal high-resolution sizing techniques, especially in complex biological media. Unfortunately, despite its limitations, due to its accessibility, low cost, and easy handling, batch mode dynamic light scattering (DLS) is still...
2 CitationsSource
#1Iwona CichaH-Index: 20
#2Cédric Chauvierre (Paris Diderot University)H-Index: 13
Last. Didier Letourneur (Paris Diderot University)H-Index: 39
view all 15 authors...
Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicomponent nano-sized products poses multiple technical...
8 CitationsSource
#1Jasmin Matuszak (FAU: University of Erlangen-Nuremberg)H-Index: 9
#2Philipp Dörfler (FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Iwona Cicha (FAU: University of Erlangen-Nuremberg)H-Index: 20
view all 16 authors...
AbstractThe objective of our work was to investigate the effects of different types of nanoparticles on endothelial (HUVEC) and monocytic cell functions. We prepared and tested 14 different nanosys...
2 CitationsSource