Alexander R. Opotowsky
Boston Children's Hospital
Publications 226
Background: Thromboembolism (TE) and Fontan-associated liver disease (FALD) are common and lead to significant morbidity in Fontan circulations. Risk factors for TE and the potential link between TE and FALD are not well understood. The objective of this study was to evaluate the association between TE and the severity of FALD based on radiologic liver stiffness. Methods: Using a retrospective cohort study design, 85 Fontan patients (aged 27.7 ± 8.2 years) who had liver stiffness measurement wer...
#1Jonathan N. Menachem (VUMC: Vanderbilt University Medical Center)H-Index: 4
#2Alexander R. Opotowsky (Brigham and Women's Hospital)H-Index: 32
#1Kate H. MarshallH-Index: 1
#2Yves d ’UdekemH-Index: 30
Last.Nadine A. KasparianH-Index: 20
view all 9 authors...
Introduction: People with a Fontan circulation may experience disease-related challenges alongside, or as a result, of their medical pathway. Little is known about the impact of these experiences o...
#1Danielle S. Burstein (Children's Hospital of Philadelphia)H-Index: 2
#2Jonathan N. Menachem (VUMC: Vanderbilt University Medical Center)H-Index: 4
Last.Alexander R. Opotowsky (Brigham and Women's Hospital)H-Index: 32
view all 3 authors...
Congenital heart disease (CHD)–related heart failure is common and associated with significant morbidity, mortality, and resource utilization. In adults with CHD (ACHD), exercise limitation is often underestimated. Quantitative assessment with cardiopulmonary exercise testing (CPET) provides a comprehensive evaluation of exercise capacity and can help risk stratify patients, particularly across serial testing. CPET parameters must be interpreted within the context of the underlying anatomy, spec...
#1Kathryn H. Melamed (UCLA: University of California, Los Angeles)H-Index: 1
#2Mário Santos (Brigham and Women's Hospital)H-Index: 13
Last.David M. Systrom (Brigham and Women's Hospital)H-Index: 31
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Purpose The clinical investigation of exertional intolerance generally focuses on cardiopulmonary diseases, while peripheral factors are often overlooked. We hypothesize that a subset of patients exists whose predominant exercise limitation is due to abnormal systemic oxygen extraction (SOE).
#2Bradley M. Wertheim (Brigham and Women's Hospital)H-Index: 6
Last.Ryan J. Tedford (MUSC: Medical University of South Carolina)H-Index: 23
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#1Catherine Deshaies (UdeM: Université de Montréal)H-Index: 1
#2Robert M. Hamilton (U of T: University of Toronto)H-Index: 33
Last.Paul Khairy (UdeM: Université de Montréal)H-Index: 45
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Abstract Background Thromboembolic events contribute greatly to morbidity and mortality following Fontan surgery for univentricular hearts. Objectives This study sought to evaluate the effect of type of Fontan surgery on thromboembolic risk. Methods A North American multicenter retrospective cohort study enrolled 522 patients with Fontan palliation consisting of an atriopulmonary connection (APC) (21.4%), lateral tunnel (LT) (41.8%), or extracardiac conduit (EC) (36.8%). Thromboembolic complicat...
2 CitationsSource
#1Jingyi Gong (Brigham and Women's Hospital)
#2Renata R.T. Castro (Brigham and Women's Hospital)
Last.John D. Groarke (Brigham and Women's Hospital)H-Index: 15
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Background Minute ventilation-carbon dioxide production relationship (VE/VCO2 slope), as assessed by cardiopulmonary exercise testing (CPET), strongly predicts outcomes in heart failure (HF). High VE/VCO2 slope can indicate ventilatory inefficiency. A single VE/VCO2 slope threshold defining abnormal of ≥ 34 to 36 is used clinically across HF categories; however, this threshold has been validated largely in patients with reduced left ventricular ejection fraction (LVEF). Objectives To examine the...
#1Alexander R. Opotowsky (Brigham and Women's Hospital)H-Index: 32
#2Matthew Carazo (Brigham and Women's Hospital)H-Index: 1
Last.Saurabh Rajpal (Nationwide Children's Hospital)H-Index: 4
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Background Glomerular filtration rate is a key physiologic variable with a central role in clinical decision making and a strong association with prognosis in diverse populations. Reduced estimated glomerular filtration rate (eGFR) is common among adults with congenital heart disease (ACHD). Methods We conducted a prospective cohort study of outpatient ACHD ≥18 years old seen in 2012-2017. Creatinine and cystatin C were measured; eGFR was calculated using either the creatinine or cystatin C Chro...
1 CitationsSource
#1Saurabh Rajpal (Nationwide Children's Hospital)H-Index: 4
#2Fred M. Wu (Brigham and Women's Hospital)H-Index: 11
Last.Alexander R. Opotowsky (Brigham and Women's Hospital)H-Index: 32
view all 3 authors...