Philip W.J. Burnet
University of Oxford
EndocrinologyHippocampal formationReceptorHippocampusBiology
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Publications 79
#1Robin I. M. DunbarH-Index: 89
#2Amar SarkarH-Index: 6
Last. Philip W.J. BurnetH-Index: 31
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#1Nicola Johnstone (University of Surrey)
#2Chiara Milesi (University of Surrey)
Last. Kathrin Cohen Kadosh (University of Surrey)
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Current research implicates pre- and probiotic supplementation as potential mediators for improving symptomology in numerous physical and emotional ailments. The alteration of emotional states via nutrient intake is an attractive concept for clinicians and consumers alike and may be an efficient channel to improved well-being. Here we focus on the period of late adolescence, which is a time of emotional refinement via maturation that significantly influences emotional, social and physical well-b...
#1Liliana Capitao (University of Oxford)H-Index: 6
#2Rita Baião (University of Oxford)H-Index: 1
Last. Philip W.J. Burnet (University of Oxford)H-Index: 31
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Based on the emerging interest in the effects of gut microbiota on cognition, this proof-of-concept study assessed how children aged 7 to 9 with low reading scores responded to the ingestion of a 3...
#1Kao Ac-C. (University of Oxford)H-Index: 1
#2K W Chan (University of Oxford)H-Index: 1
Last. Philip W.J. Burnet (University of Oxford)H-Index: 31
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Abstract The intestinal microbiome is emerging as a novel therapeutic target owing to the wide range of potential health benefits that could result by manipulating the microbiota composition through relatively simple interventions. Ingestion of the prebiotic Bimuno™ galacto-oligosaccharide (B-GOS®) is one such intervention that has been shown to attenuate olanzapine-induced weight gain and improve cognitive flexibility in rats, potentially through mechanisms involving acetate, the major short-ch...
1 CitationsSource
#1Amy Chia-Ching Kao (University of Oxford)H-Index: 1
#2Philip W.J. Burnet (University of Oxford)H-Index: 31
Last. Belinda R. Lennox (University of Oxford)H-Index: 22
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Abstract Schizophrenia is among the top half of the 25 leading causes of disabilities worldwide with a 10–20 year decrease in life expectancy. Ineffective pharmacotherapy in the management of cognitive deficits and weight gain are known to be significant contributors; therefore interventions that may mitigate one, or both, of these parameters would be highly beneficial. Manipulation of the gut microbiome using dietary supplements such as prebiotics may be one such intervention. Preclinical studi...
4 CitationsSource
#1Amar Sarkar (University of Cambridge)H-Index: 6
#2Siobhán Harty (University of Oxford)H-Index: 6
Last. Philip W.J. Burnet (University of Oxford)H-Index: 31
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Psychology and microbiology make unlikely friends, but the past decade has witnessed striking bidirectional associations between intrinsic gut microbes and the brain, relationships with largely untested psychological implications. Although microbe–brain relationships are receiving a great deal of attention in biomedicine and neuroscience, psychologists have yet to join this journey. Here, we illustrate microbial associations with emotion, cognition, and social behavior. However, despite consider...
24 CitationsSource
#1Benjamin Gronier (DMU: De Montfort University)H-Index: 5
Last. Philip W.J. Burnet (University of Oxford)H-Index: 31
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Abstract We have previously shown that prebiotics (dietary fibres that augment the growth of indigenous beneficial gut bacteria) such as Bimuno™ galacto-oligosaccharides (B-GOS®), increased N-methyl-D-aspartate (NMDA) receptor levels in the rat brain. The current investigation examined the functional correlates of these changes in B-GOS®-fed rats by measuring cortical neuronal responses to NMDA using in vivo NMDA micro-iontophoresis electrophysiology, and performance in the attentional set-shift...
12 CitationsSource
#1Shi Yu Chan (University of Oxford)H-Index: 1
#2Edward Matthews (Green Templeton College)H-Index: 1
Last. Philip W.J. Burnet (University of Oxford)H-Index: 31
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Since the discovery that a single dose of ketamine, an NMDA receptor (NMDAR) antagonist, had rapid and long-lasting antidepressant effects, there has been increased interest in using NMDAR modulators in the pharmacotherapy of depression. Ketamine’s efficacy seems to imply that depression is a disorder of NMDAR hyperfunctionality. However, studies showing that not all NMDAR antagonists are able to act as antidepressants challenge this notion. Furthermore, NMDAR co-agonists have also been gaining ...
10 CitationsSource
#1Amar Sarkar (University of Oxford)H-Index: 6
#2Soili M. Lehto (University of Eastern Finland)H-Index: 30
Last. Philip W.J. Burnet (University of Oxford)H-Index: 31
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Psychobiotics were previously defined as live bacteria (probiotics) which, when ingested, confer mental health benefits through interactions with commensal gut bacteria. We expand this definition to encompass prebiotics, which enhance the growth of beneficial gut bacteria. We review probiotic and prebiotic effects on emotional, cognitive, systemic, and neural variables relevant to health and disease. We discuss gut–brain signalling mechanisms enabling psychobiotic effects, such as metabolite pro...
132 CitationsSource