Lourdes Rocamora-Reverte
Universidad Miguel Hernández de Elche
Publications 19
#1Silvina GrassoH-Index: 5
#2Elena Tristante (Arkansas Electric Cooperative Corporation)H-Index: 4
Last.Isabel Martínez-Lacaci (Arkansas Electric Cooperative Corporation)H-Index: 8
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Selumetinib (AZD6244, ARRY-142886) is a MEK1/2 inhibitor that has gained interest as an anti-tumour agent. We have determined the degree of sensitivity/resistance to Selumetinib in a panel of colorectal cancer cell lines using cell proliferation and soft agar assays. Sensitive cell lines underwent G1 arrest, whereas Selumetinib had no effect on the cell cycle of resistant cells. Some of the resistant cell lines showed high levels of ERK1/2 phosphorylation in the absence of serum. Selumetinib inh...
12 CitationsSource
#1Alberto Valdés (CSIC: Spanish National Research Council)H-Index: 14
#2Virginia García-Cañas (CSIC: Spanish National Research Council)H-Index: 31
Last.Alejandro Cifuentes (CSIC: Spanish National Research Council)H-Index: 56
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In this work, the effect of rosemary extracts rich on polyphenols obtained using pressurized fluids was investigated on the gene expression of human SW480 and HT29 colon cancer cells. The application of transcriptomic profiling and functional enrichment analysis was done via two computational approaches, Ingenuity Pathway Analysis and Gene Set Enrichment Analysis. These two approaches were used for functional enrichment analysis as a previous step for a reliable interpretation of the data obtain...
42 CitationsSource
#1Alberto Valdés (CSIC: Spanish National Research Council)H-Index: 14
#2Carolina Simó (CSIC: Spanish National Research Council)H-Index: 33
Last.Alejandro Cifuentes (CSIC: Spanish National Research Council)H-Index: 56
view all 7 authors...
Funded by: Ministerio de Ciencia e Innovacion, Spain. Grant Numbers: AGL2008-05108-C03-01, AGL2008-05108-C03-02, AGL2011-29857-C03-01 and Ministerio de Educacion y Ciencia, Spain. Grant Number: CSD2007-00063 FUN-C-FOOD.
42 CitationsSource
#1Clara Ibáñez (CSIC: Spanish National Research Council)H-Index: 17
#2Alberto Valdés (CSIC: Spanish National Research Council)H-Index: 14
Last.Alejandro Cifuentes (CSIC: Spanish National Research Council)H-Index: 56
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Abstract A global methodology, called Foodomics, which allows carrying out a comprehensive evaluation of the health benefits of food ingredients is presented in this work. The new methodology is based on the combination of several analytical platforms and data processing for Transcriptomics, Proteomics and Metabolomics studies, allowing the determination of changes induced by food ingredients at molecular level. Both, the whole methodological development and its potential are presented through t...
79 CitationsSource
#1Miguel Herrero (CSIC: Spanish National Research Council)H-Index: 43
#2María Castro-Puyana (CSIC: Spanish National Research Council)H-Index: 21
Last.Elena Ibáñez (CSIC: Spanish National Research Council)H-Index: 56
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Abstract Although subcritical water extraction (SWE) has already shown its great potential for the attainment of natural bioactive extracts, concerns still remain on possible unexpected reactions that can arise during the extraction process, usually taking place at high pressure and temperature. It is already well-known that different components might be formed during the SWE extraction protocol due e.g. to Maillard reaction, which can improve the bioactivity of the obtained extracts. On the oth...
19 CitationsSource
#1Salvador Fernández-Arroyo (UGR: University of Granada)H-Index: 23
Last.J.A. FerragutH-Index: 15
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Abstract Crude phenolic extracts (PE) have been obtained from naturally bearing Spanish extra-virgin olive oil (EVOO) showing different polyphenol families such as secoiridoids, phenolic alcohols, lignans, and flavones. EVOO-derived complex phenols (especially from the Arbequina variety olive) have been shown to suppress cell growth of SW480 and HT29 human colon adenocarcinoma cell lines. Inhibition of proliferation by EVOO-PE Arbequina variety extract was accompanied by apoptosis in both colon-...
30 CitationsSource
#1Lourdes Rocamora-Reverte (Universidad Miguel Hernández de Elche)H-Index: 8
#2Estefanía Carrasco-García (Universidad Miguel Hernández de Elche)H-Index: 10
Last.Santiago Gómez-Ruiz (URJC: King Juan Carlos University)H-Index: 25
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A group of organotin(IV) complexes were prepared: [SnCy3(DMNI)] (1), [SnCy3(BZDO)] (2), [SnCy3(DMFU)] (3), and [SnPh2(BZDO)2] (4), for which DMNIH=2,6-dimethoxynicotinic acid, BZDOH=1,4-benzodioxane-6-carboxylic acid, and DMFUH=2,5-dimethyl-3-furoic acid. The cytotoxic activities of compounds 1–4 were tested against pancreatic carcinoma (PANC-1), erythroleukemia (K562), and two glioblastoma multiform (U87 and LN-229) human cell lines; they show very high antiproliferative activity, with IC50 val...
26 CitationsSource
#1Miguel Herrero (CSIC: Spanish National Research Council)H-Index: 43
Last.Elena IbáñezH-Index: 2
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Trabajo presentado al 10th International Symposium on Supercritical Fluids celebrado del 13 al 16 de mayo de 2012 en San Francisco (US).
#2Alberto ValdésH-Index: 14
Last.Virginia García-CañasH-Index: 31
view all 9 authors...
Resumen del trabajo presentado al 18th Latin-American Symposium on Biotechnology, Biomedical, Biopharmaceutical and Industrial Applications of Capillary Electrophoresis and Microchip Technology celebrado del 2 al 5 de diciembre de 2012 en Buenos Aires (Argentina).
#1Zhao HongmeiH-Index: 1
#2Ji Yean KwonH-Index: 2
Last.Hitoshi MaedaH-Index: 34
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2 Citations