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Emmelie Cansby
University of Gothenburg
13Publications
8H-index
208Citations
Publications 13
Newest
#1Silva SüttH-Index: 4
#2Emmelie CansbyH-Index: 8
Last.Margit MahlapuuH-Index: 20
view all 12 authors...
Whole-body energy homeostasis at over-nutrition critically depends on how well adipose tissue remodels in response to excess calories. We recently identified serine/ threonine protein kinase (STK)25 as a critical regulator of ectopic lipid storage in non-adipose tissue and systemic insulin resistance in the context of nutritional stress. Here, we investigated the role of STK25 in regulation of adipose tissue dysfunction in mice challenged with a high-fat diet. We found that overexpression of STK...
Objective— Recent cohort studies have shown that nonalcoholic fatty liver disease, and especially nonalcoholic steatohepatitis, associate with atherosclerosis and cardiovascular disease, independently of conventional cardiometabolic risk factors. However, the mechanisms underlying the pathophysiological link between nonalcoholic fatty liver disease/nonalcoholic steatohepatitis and cardiovascular disease still remain unclear. Our previous studies have identified STK25 (serine/threonine protein ki...
#1Esther Nuñez-Durán (Sahlgrenska University Hospital)H-Index: 6
#2Belén Chanclón (University of Gothenburg)H-Index: 4
Last.Margit Mahlapuu (Sahlgrenska University Hospital)H-Index: 20
view all 8 authors...
#1Manoj Amrutkar (University of Gothenburg)H-Index: 9
#2Matthias Kern (Leipzig University)H-Index: 17
Last.Margit Mahlapuu (University of Gothenburg)H-Index: 20
view all 10 authors...
Aims/hypothesis Type 2 diabetes is closely associated with pathological lipid accumulation in the liver, which is suggested to actively contribute to the development of insulin resistance. We recently identified serine/threonine protein kinase 25 (STK25) as a regulator of liver steatosis, whole-body glucose tolerance and insulin sensitivity in a mouse model system. The aim of this study was to assess the role of STK25 in the control of lipid metabolism in human liver.
#1Manoj Amrutkar (University of Gothenburg)H-Index: 9
#2Emmelie Cansby (University of Gothenburg)H-Index: 8
Last.Margit Mahlapuu (University of Gothenburg)H-Index: 20
view all 14 authors...
Understanding the molecular networks controlling ectopic lipid deposition, glucose tolerance, and insulin sensitivity is essential to identifying new pharmacological approaches to treat type 2 diabetes. We recently identified serine/threonine protein kinase 25 (STK25) as a negative regulator of glucose and insulin homeostasis based on observations in myoblasts with acute depletion of STK25 and in STK25-overexpressing transgenic mice. Here, we challenged Stk25 knockout mice and wild-type litterma...
#1Manoj Amrutkar (University of Gothenburg)H-Index: 9
#2Emmelie Cansby (University of Gothenburg)H-Index: 8
Last.Margit Mahlapuu (University of Gothenburg)H-Index: 20
view all 9 authors...
Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease, and 10% to 20% of NAFLD patients progress to nonalcoholic steatohepatitis (NASH). The molecular pathways controlling progression to NAFLD/NASH remain poorly understood. We recently identified serine/threonine protein kinase 25 (STK25) as a regulator of whole-body insulin and glucose homeostasis. This study investigates the role of STK25 in liver lipid accumulation and NASH. Stk25 transgenic mice challenged with a ...
#1Emmelie Cansby (University of Gothenburg)H-Index: 8
#2Annika Nerstedt (University of Gothenburg)H-Index: 10
Last.Margit Mahlapuu (University of Gothenburg)H-Index: 20
view all 6 authors...
Interleukin-6 (IL-6) induces hepatic inflammation and insulin resistance, and therapeutic strategies to counteract the IL-6 action in liver are of high interest. In this study, we demonstrate that acute treatment with AMP-activated protein kinase (AMPK) agonists AICAR and metformin efficiently repressed IL-6-induced hepatic proinflammatory gene expression and activation of STAT3 in a mouse model of diet-induced type 2 diabetes, bringing it back to basal nonstimulated level. Surprisingly, the inf...
#1Emmelie CansbyH-Index: 8
Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder that has reached epidemic proportions globally, and is now considered to be one of the main threats to human health. The currently available treatment options in T2DM suffer from inadequate efficacy and durability, as well as liabilities, including hypoglycemia, weight gain, edema and gastrointestinal intolerance. Since the efficacy and patient compliance of existing treatments are in many cases unsatisfactory, there is a pronoun...
#1Emmelie CansbyH-Index: 8
#2Manoj AmrutkarH-Index: 9
Last.Margit MahlapuuH-Index: 20
view all 11 authors...
Partial depletion of serine/threonine protein kinase 25 (STK25), a member of the Ste20 superfamily of kinases, increases lipid oxidation and glucose uptake in rodent myoblasts. Here we show that transgenic mice overexpressing STK25, when challenged with a high-fat diet, develop reduced glucose tolerance and insulin sensitivity compared to wild-type siblings, as evidenced by impairment in glucose and insulin tolerance tests as well as in euglycemic-hyperinsulinemic clamp studies. The fasting plas...
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