Georgios Lyratzopoulos
University College London
Publications 154
One in three colon cancers are diagnosed as an emergency, which is associated with worse cancer outcomes. Chronic conditions (comorbidities) affect large proportions of adults and they might influence the risk of emergency presentations (EP). We aimed to evaluate the effect of specific pre-existing comorbidities on the risk of colon cancer being diagnosed following an EP rather than through non-emergency routes. The cohort study included 5745 colon cancer patients diagnosed in England 2005–2010,...
#1Fiona M Walter (University of Cambridge)H-Index: 33
#2Matthew Thompson (UW: University of Washington)H-Index: 43
Last.Greg Rubin (RVI: Royal Victoria Infirmary)H-Index: 21
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Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, ...
#1Silvia C Mendonca (University of Cambridge)H-Index: 7
#2Gary A. Abel (University of Exeter)H-Index: 29
Last.Martin Roland (University of Cambridge)H-Index: 67
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Cancer Research UK / National Awareness and Early Diagnosis Initiative Project Grant No. C18081/A17854; Cancer Research UK Advanced Clinician Scientist Fellowship No. C18081/A18180
#1Annie Herbert (UCL: University College London)H-Index: 12
#2Gary A Abel (PHE: Public Health England)H-Index: 1
Last.Georgios Lyratzopoulos (UCL: University College London)H-Index: 21
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Background Diagnosis of cancer as an emergency is associated with poor outcomes but has a complex aetiology. Examining determinants and time trends in diagnostic routes can help to appreciate the critical role of general practice over time in diagnostic pathways for patients with cancer. Aim To examine sociodemographic, cancer site, and temporal associations with type of presentation among patients with cancer diagnosed as emergencies. Design and setting Analysis of Routes to Diagnosis data, 200...
#1P. Sheridan (UCSD: University of California, San Diego)
Last.Caroline A. Thompson (UCSD: University of California, San Diego)H-Index: 1
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#1Mm Koo (UCL: University College London)H-Index: 3
#2Greg Rubin (Newcastle University)H-Index: 21
Last.Georgios Lyratzopoulos (UCL: University College London)H-Index: 21
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Objectives Cancer can be diagnosed in the absence of tumour-related symptoms, but little is known about the frequency and circumstances preceding such diagnoses which occur outside participation in screening programmes. We aimed to examine incidentally diagnosed cancer among a cohort of cancer patients diagnosed in England. Design Cross-sectional study of national primary care audit data on an incident cancer patient population. Setting We analysed free-text information on the presenting feature...
#1Clare Pearson (PHE: Public Health England)
#2Jess Fraser (PHE: Public Health England)
Last.Georgios Lyratzopoulos (UCL: University College London)H-Index: 21
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Abstract Background Diagnostic timeliness in cancer patients is important for clinical outcomes and patient satisfaction but, to-date, continuous monitoring of diagnostic intervals in nationwide incident cohorts has been impossible in England. Methods We developed a new methodology for measuring the secondary care diagnostic interval (SCDI - first relevant secondary care contact to diagnosis) using linked cancer registration and healthcare utilisation data. Using this method, we subsequently exa...