Georgios Lyratzopoulos
University College London
Publications 219
#1Cristina Renzi (UCL: University College London)H-Index: 11
#2Georgios Lyratzopoulos (UCL: University College London)H-Index: 35
Last.Bernard Rachet (Lond: University of London)H-Index: 35
view all 5 authors...
One in three colon cancers are diagnosed as an emergency, which is associated with worse cancer outcomes. Chronic conditions (comorbidities) affect large proportions of adults and they might influence the risk of emergency presentations (EP). We aimed to evaluate the effect of specific pre-existing comorbidities on the risk of colon cancer being diagnosed following an EP rather than through non-emergency routes. The cohort study included 5745 colon cancer patients diagnosed in England 2005–2010,...
1 CitationsSource
Abstract Background There is a growing emphasis on the speed of diagnosis as an aspect of cancer prognosis. While epidemiological data in the last decade have quantified diagnostic timeliness and its variation, whether and how often prolonged diagnostic intervals can be considered avoidable is unknown. Methods We used data from the English National Cancer Diagnosis Audit (NCDA) on 17,042 patients diagnosed with cancer in 2014. Participating primary care physicians were asked to identify delays i...
1 CitationsSource
#1Annie Herbert (UoB: University of Bristol)H-Index: 13
#2Sam Winters (PHE: Public Health England)H-Index: 1
Last.Gary A. Abel (University of Exeter)H-Index: 30
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Abstract Background Diagnosis of cancer through an emergency presentation is associated with worse clinical and patient experience outcomes. The proportion of patients with cancer who are diagnosed through emergency presentations has consequently been introduced as a routine cancer surveillance measure in England. Welcome reductions in this metric have been reported over more than a decade but whether reductions reflect true changes in how patients are diagnosed rather than the changing case-mix...
#1Fiona M Walter (University of Cambridge)H-Index: 34
#2Matthew Thompson (UW: University of Washington)H-Index: 32
Last.Jon Emery (University of Melbourne)H-Index: 42
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Background Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and qualit...
Background:Surveys collecting patient experience data often contain a large number of items covering a wide range of experiences. Knowing which areas to prioritize for improvements efforts can be d...
Abstract Background Immunodeficiency syndromes (acquired/congenital/iatrogenic) are known to increase Hodgkin’s lymphoma (HL) risk, but the effect of allergic immune dysregulation and corticosteroids are poorly understood. Objective To assess the risk of HL associated with allergic disease (asthma, eczema and allergic rhinitis) and corticosteroid use. Methods We conducted a case-control study using the UK Clinical Practice Research Datalink (CPRD) linked to hospital data. Multivariable logistic ...
Summary Background Early diagnosis interventions such as symptom awareness campaigns increasingly form part of global cancer control strategies. However, these strategies will have little impact in improving cancer outcomes if the targeted symptoms represent advanced stage of disease. Therefore, we aimed to examine associations between common presenting symptoms of cancer and stage at diagnosis. Methods In this cross-sectional study, we analysed population-level data from the English National Ca...
1 CitationsSource
#1Silvia C Mendonca (University of Cambridge)H-Index: 7
#2Gary A. Abel (University of Exeter)H-Index: 30
Last.Georgios Lyratzopoulos (University of Cambridge)H-Index: 35
view all 11 authors...
Cancer Research UK / National Awareness and Early Diagnosis Initiative Project Grant No. C18081/A17854; Cancer Research UK Advanced Clinician Scientist Fellowship No. C18081/A18180
1 CitationsSource
#1Annie Herbert (UCL: University College London)H-Index: 13
#2Gary A Abel (PHE: Public Health England)H-Index: 1
Last.Georgios Lyratzopoulos (UCL: University College London)H-Index: 35
view all 6 authors...
Background Diagnosis of cancer as an emergency is associated with poor outcomes but has a complex aetiology. Examining determinants and time trends in diagnostic routes can help to appreciate the critical role of general practice over time in diagnostic pathways for patients with cancer. Aim To examine sociodemographic, cancer site, and temporal associations with type of presentation among patients with cancer diagnosed as emergencies. Design and setting Analysis of Routes to Diagnosis data, 200...
1 CitationsSource