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Naoki Toyooka
University of Toyama
160Publications
21H-index
1,439Citations
Publications 160
Newest
#1Satoshi Endo (Gifu Pharmaceutical University)H-Index: 19
#2Mai Uchibori (Gifu Pharmaceutical University)
Last.Yuji O. Kamatari (Gidai: Gifu University)H-Index: 19
view all 14 authors...
Abstract Autophagy induction in tumors is implicated in tumor malignancy and acquisition of anticancer-drug resistance, and hence, autophagy inhibitors are expected as novel anticancer agents. Atg4B, a cysteine proteinase, is a key enzyme in autophagy process, and considered as one of desirable targets for development of selective autophagy inhibitors. In this study, to search novel inhibitors of Atg4B, we employed the virtual screening approach and differential scanning fluorimetry analysis, an...
#1Huy Du Nguyen (University of Toyama)H-Index: 2
#2Takuya Okada (University of Toyama)H-Index: 2
Last.Naoki Toyooka (University of Toyama)H-Index: 21
view all 7 authors...
Prenylated flavonoids have attracted much attention due to their promising and diverse bioactivities on multitarget tissues. To the best of our knowledge, our recent studies demonstrated first that...
#1Hideki KawashimaH-Index: 7
#2Naoki ToyookaH-Index: 21
Last.Ken-ichi KimuraH-Index: 23
view all 8 authors...
Diverse non-methylene-interrupted (NMI) fatty acids (FAs) with odd-chain lengths have been recognized in triacylglycerols and polar lipids from the ovaries of the limpet Cellana toreuma, however their biological properties remain unclear. In this study, two previously unreported odd-chain NMI FAs, (12Z)-12,16-heptadecadienoic (1) and (14Z)-14,18-nonadecadienoic (2) acids, from the ovary lipids of C. toreuma were identified by a combination of equivalent chain length (ECL) values of their methyl ...
Abstract Human pancreatic tumor cells have inherent ability to tolerate nutrition starvation which enables them to survive in the hypovascular tumor microenvironment. Discovery of agents that selectively inhibit the cancer cells’ tolerance to nutrition starvation leading to cancer cell death is a new anti-austerity approach in anti-cancer drug discovery. A series of coumarins derivatives were synthesized and evaluated for their anti-austerity activity against PANC-1 human pancreatic cancer cell ...
#2Daichi Hayakawa (Showa University)H-Index: 2
Last.Naoki ToyookaH-Index: 21
view all 4 authors...
Marine tricyclic alkaloids lepadiformine and fasicularin, with a unique perhydropyrrolo[2,1-j]quinoline or perhydropyrido[2,1-j]quinoline framework, were synthesized starting from the B ring of the tricyclic system. This approach includes a highly stereocontrolled diallylation of a cyclic enaminoester and subsequent ring-closing metathesis to construct the A/B ring system, which was transformed into key lactams 32 and 33, and amino alcohol 37. Thus, we achieved formal syntheses of (−)-lepadiform...
#1Hiroshi Tsuneki (University of Toyama)H-Index: 24
#2Hitomi Yoshida (University of Toyama)H-Index: 1
Last.Toshiyasu Sasaoka (University of Toyama)H-Index: 35
view all 10 authors...
Abstract Brain-derived neurotrophic factor (BDNF), an essential factor for maintaining brain functions, has been reported to be reduced in various neurological diseases, including Alzheimer's disease and major depression. Therefore, new drugs to increase the BDNF expression need to be developed. Since phosphatidylinositol (3,4,5)-trisphosphate, a membrane signaling molecule produced by phosphoinositide 3 (PI3)-kinase in the BDNF signaling, is a candidate target of SH2 domain-containing inositol ...
#1Masashi Kawasaki (Toyama Prefectural University)H-Index: 11
#2Saki Kuroyanagi (University of Toyama)H-Index: 1
Last.Naoki Toyooka (University of Toyama)H-Index: 21
view all 6 authors...
#1Ichiro Takasaki (University of Toyama)H-Index: 23
#2Koji Nakamura (University of Toyama)
Last.Takashi Kurihara (Kadai: Kagoshima University)H-Index: 15
view all 9 authors...
Abstract We recently developed PA-8, a novel small-molecule antagonist of PACAP type 1 (PAC1) receptor. In the present study, we examined whether PA-8 was effective against formalin-induced inflammatory pain in mice. Both intrathecal and oral administration of PA-8 resulted in the dose-dependent attenuation of the second phase of formalin-induced nociceptive responses. PA-8 also inhibited c-fos upregulation in the ipsilateral dorsal horn of the spinal cord. The results suggested that PACAP-PAC1 ...
#1Shiori Tomita (Kindai University)H-Index: 3
#2Fumiko Sekiguchi (Kindai University)H-Index: 25
Last.Naoki Toyooka (University of Toyama)H-Index: 21
view all 11 authors...
Abstract Bortezomib, a first-line agent for treatment of multiple myeloma, exhibits anticancer activity through proteasome inhibition. However, bortezomib-induced peripheral neuropathy (BIPN) is one of the most serious side effects. Since decreased proteasomal degradation of Ca v 3.2 T-type calcium channels in the primary afferents is involved in persistent pain, we investigated whether BIPN involves increased protein levels of Ca v 3.2 in mice. Six repeated i.p. administrations of bortezomib fo...
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