Wen Wu
Shanghai Jiao Tong University
Autophagy-related protein 13AutophagyOsteoclastAtg1PI3K/AKT/mTOR pathway
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#1Lingjie Fu (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Wen Wu (SJTU: Shanghai Jiao Tong University)
Last. Pu Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 3
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Autophagy is an evolutionarily conserved dynamic process and present in variety of cells at basal levels to maintain homeostasis and to promote cell survival in response to stresses. The early bone loss with excessive glucocorticoids (GCs) was reported to be related with the extension of the life span of osteoclasts. However, the connection between GCs induced bone loss and osteoclast autophagy remains to be elucidated. Autophagy was detected in a Dexamethasone (Dex) induced osteoporotic mice mo...
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