P’ng Loke
National Institutes of Health
ImmunologyColonizationGranulocyteType 2 immune responseTissue homeostasisBiologyImmune systemMetadata
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Publications 3
#1William C. Gause (RU: Rutgers University)H-Index: 56
#2Carla V. Rothlin (Yale University)H-Index: 26
Last. P’ng Loke (NIH: National Institutes of Health)H-Index: 1
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Type 2 immune responses operate under varying conditions in distinct tissue environments and are crucial for protection against helminth infections and for the maintenance of tissue homeostasis. Here we explore how different layers of heterogeneity influence type 2 immunity. Distinct insults, such as allergens or infections, can induce type 2 immune responses through diverse mechanisms, and this can have heterogeneous consequences, ranging from acute or chronic inflammation to deficits in immune...
1 CitationsSource
#1Frank Yeung (NYU: New York University)H-Index: 4
#2Ying Han Chen (NYU: New York University)H-Index: 2
Last. Charlotte Drake-Dunn (NYU: New York University)H-Index: 2
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Summary Free-living mammals, such as humans and wild mice, display heightened immune activation compared with artificially maintained laboratory mice. These differences are partially attributed to microbial exposure as laboratory mice infected with pathogens exhibit immune profiles more closely resembling that of free-living animals. Here, we examine how colonization by microorganisms within the natural environment contributes to immune system maturation by releasing inbred laboratory mice into ...
6 CitationsSource
#1Jacqueline M. LeungH-Index: 13
#2Sarah A. BudischakH-Index: 12
Last. Andrea L. GrahamH-Index: 29
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Metadata file describing the individual mice used in the STAT6-/- experiment are presented. Mice are distinguished by their ID number. Data on location, infection status, endpoint worm information, and immune responses are presented. Worm length/biomass and immune data have been log-transformed to meet assumptions of analysis.