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Anna Freydenzon
University of Queensland
DNA methylationAmyotrophic lateral sclerosisCohortArea under the curveConfounding
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#1Marta F. Nabais (UQ: University of Queensland)
#1Marta F. Nabais (UQ: University of Queensland)H-Index: 1
Last. Anna Freydenzon (UQ: University of Queensland)
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We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. We found a significantly higher proportion of neutrophils in cases compared to controls which replicated in an independent cohort from the Netherlands (1159 cases and 637 controls). The OSCA MOMENT linear mixed model has been shown i...
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