Αντωνία Τριχοπούλου
CancerEuropean Prospective Investigation into Cancer and NutritionProspective cohort studyMedicineCohort
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Publications 775
#1Nathalie Kliemann (IARC: International Agency for Research on Cancer)H-Index: 2
#2Neil Murphy (IARC: International Agency for Research on Cancer)H-Index: 27
Last. Mark J. Gunter (IARC: International Agency for Research on Cancer)H-Index: 46
view all 41 authors...
Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline ...
1 CitationsSource
#1Hongwei Tang (University of Texas MD Anderson Cancer Center)
#1Hongwei Tang (University of Texas MD Anderson Cancer Center)H-Index: 11
Last. Steven Gallinger (Lunenfeld-Tanenbaum Research Institute)H-Index: 80
view all 71 authors...
Background:Obesity and diabetes are major modifiable risk factors for pancreatic cancer. Interactions between genetic variants and diabetes/obesity have not previously been comprehensively investigated in pancreatic cancer at the genome-wide level. Methods:We conducted a gene-environment interaction (GxE) analysis including 8,255 cases and 11,900 controls from four pancreatic cancer GWAS datasets (PanScan I-III and PanC4). Obesity (BMI=30 kg/m2) and diabetes (duration = 3 years) were the environ...
#1Iris Cervenka (Université Paris-Saclay)H-Index: 5
#2Marie Al Rahmoun (Université Paris-Saclay)
Last. Marina Kvaskoff (Université Paris-Saclay)H-Index: 22
view all 41 authors...
Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Information on exogenous hormone use at baseline was derived from country-spec...
1 CitationsSource
#1Roland Wedekind (IARC: International Agency for Research on Cancer)H-Index: 2
#2Agneta Kiss (IARC: International Agency for Research on Cancer)H-Index: 2
Last. Julie A. Schmidt (CEU: Cancer Epidemiology Unit)H-Index: 14
view all 30 authors...
BACKGROUND Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited. OBJECTIVES To investigate the effect of red and processed meat intake on AC concentrations in plasma and urine using a r...
Purpose In this study, we aimed to study the correlation between acute and habitual intakes of flavonols, their main food sources and their 24-h urinary concentrations in an European population.
#1Leila Lujan-BarrosoH-Index: 21
#2Edoardo BotteriH-Index: 36
Last. Lambertus A. Kiemeney (Radboud University Nijmegen)H-Index: 102
view all 45 authors...
Background: Urothelial carcinoma (UC) is the predominant (95%) bladder cancer subtype in industrialised nations. Animal and epidemiological human studies suggest that hormonal factors may influence UC risk. Methods: We used an analytic cohort of 333 919 women from the European Prospective Investigation into Cancer and Nutrition Cohort (EPIC). Associations between hormonal factors and incident UC (overall and by tumour grade, tumour aggressiveness, and non-muscle invasive UC) risk were evaluated ...
#1Sofia Christakoudi (Imperial College London)H-Index: 3
#2Artemisia Kakourou (UoI: University of Ioannina)H-Index: 6
Last. Konstantinos K. Tsilidis (Imperial College London)H-Index: 21
view all 48 authors...
Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recr...
2 CitationsSource
#1David C. Gibbs (Emory University)H-Index: 5
#2Roberd M. Bostick (Emory University)H-Index: 47
Last. Alicia K. Heath (Imperial College London)H-Index: 6
view all 18 authors...
Lower pre-diagnostic circulating 25-hydroxyvitamin D (25[OH]D)-considered the best marker of total vitamin D exposure-is associated with higher mortality risk among colorectal cancer (CRC) patients. However, it is unknown whether this association differs by the vitamin D-binding protein (GC) isoform Gc2 (encoded by GC rs4588*C>A, Thr436Lys), which may substantially affect vitamin D metabolism and modify associations of 25(OH)D with colorectal neoplasm risk. Pre-diagnostic 25(OH)D-mortality assoc...
#1Xuemei Ji (Dartmouth College)H-Index: 3
#2Semanti Mukherjee (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 17
Last. Olga Y. Gorlova (Dartmouth College)H-Index: 24
view all 111 authors...
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2.22 × 10−3) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and re...
1 CitationsSource
#1T. KühnH-Index: 2
#1Tilman Kühn (DKFZ: German Cancer Research Center)H-Index: 31
Last. R. KaaksH-Index: 107
view all 44 authors...
BACKGROUND: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. METHODS: Associations between pre-diagnostic plasma levels of 17 primary, secondary and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid le...
1 CitationsSource