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Dirk M. Hermann
University of Medicine and Pharmacy of Craiova
EndocrinologyCardiologyCeramideAcid sphingomyelinaseStrokeIschemiaDiabetes mellitusMedicinePharmacology
7Publications
1H-index
7Citations
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Publications 3
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#1Dirk M. Hermann (University of Medicine and Pharmacy of Craiova)H-Index: 49
#1Dirk M. Hermann (University of Medicine and Pharmacy of Craiova)H-Index: 1
Last. Aurel Popa-Wagner (University of Medicine and Pharmacy of Craiova)H-Index: 1
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Major efforts are currently made promoting neuronal plasticity and brain remodeling in the postacute stroke phase. Experimental studies evaluating new stroke therapies are mostly performed in rodents, which compared to humans exhibit a short lifespan. These studies widely employ young, otherwise healthy, rodents that lack the vascular risk factors and comorbidities of stroke patients. These risk factors compromise postischemic neurological recovery and brain plasticity and in several contexts re...
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#1Janine GronewoldH-Index: 8
#2Rene KroppH-Index: 1
Last. Dirk M. HermannH-Index: 49
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Arterial hypertension promotes atherosclerosis and cardiovascular events. We evaluated how cardiovascular risk and atherosclerosis progression are associated with blood pressure, antihypertensive t...
1 CitationsSource
#1Mohamud Yusuf AH-Index: 1
#1Ayan Mohamud YusufH-Index: 1
Last. Dirk M. HermannH-Index: 1
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In this review, we summarize implications of the acid sphingomyelinase/ ceramide system in ischemic stroke. Acid sphingomyelinase catalyzes the formation of the bioactive sphingolipid ceramide which coalesces into membrane platforms and has a pivotal role in inflammation, cell signaling and death. Cerebral ischemia increases acid sphingomyelinase activity and elevates brain ceramide levels, which has been associated with the exacerbation of ischemic injury and deterioration of stroke outcome. In...
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