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Edgar Domenech-Estarellas
Internal medicineVisual analogue scaleAdverse effectTransdermalPlaceboVolunteerCorneaDiseaseDiabetes mellitusMedicine
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Chronic GvHD affects about 30-60% of patients after allogeneic hematopoietic cell transplant (allo-HCT), and a majority exhibit ocular manifestations with significant impact on quality of life. In severe cases, oGvHD can lead to permanent vision loss. There is no FDA-approved treatment to date as the current options are limited and mostly ineffective. Forehead application of 1% progesterone gel (Pro-ocularTM) increases resistance to painful corneal stimuli in animal studies, as well as improves ...
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