Clara Bredow
Humboldt University of Berlin
AutophagyCoxsackievirusISG15ProteomicsQuantitative proteomicsPI3K/AKT/mTOR pathwayBiologyCell biology
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Publications 2
#1Meike Kespohl (Humboldt University of Berlin)H-Index: 1
#2Clara Bredow (Humboldt University of Berlin)H-Index: 1
Last. Henry Fechner (Technical University of Berlin)H-Index: 11
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Protein modification with ISG15 (ISGylation) represents a major type I IFN–induced antimicrobial system. Common mechanisms of action and species-specific aspects of ISGylation, however, are still ill defined and controversial. We used a multiphasic coxsackievirus B3 (CV) infection model with a first wave resulting in hepatic injury of the liver, followed by a second wave culminating in cardiac damage. This study shows that ISGylation sets nonhematopoietic cells into a resistant state, being indi...
#1Yifeng Zhang (Roy J. and Lucille A. Carver College of Medicine)H-Index: 1
#2Fabien Thery (UGent: Ghent University)H-Index: 1
Last. Lilliana Radoshevich (Roy J. and Lucille A. Carver College of Medicine)H-Index: 1
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ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral and anti-bacterial activity. Here, we map the endogenous in vivo ISGylome in the liver following Listeria monocytogenes infection by combining murine models of reduced or enhanced ISGylation with quantitative proteomics. Our method identifies 930 ISG15 sites in 434 proteins and also detects changes in the host ubiquitylome. The ISGylated targets are enriched in proteins which alter cellular metabolic processes, including ...
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