Miki Nishio
Kobe University
Hippo signaling pathwayYAP1Hippo signalingCancer researchBiologyCell biology
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Publications 10
#1Hirofumi Omori (Kobe University)H-Index: 3
#1Hirofumi Omori (Kobe University)
Last. Hiroki HikasaH-Index: 8
view all 18 authors...
Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common group of cancers in the world, and patients have a poor prognosis. Here, we present data indicating that YAP1 may be a strong driver of the onset and progression of oral SCC (OSCC), a major subtype of HNSCC. Mice with tongue-specific deletion of Mob1a/b and thus endogenous YAP1 hyperactivation underwent surprisingly rapid and highly reproducible tumorigenesis, developing tongue carcinoma in situ within 2 weeks and invasive SC...
#1Wakako Kato (Kobe University)
#2Miki Nishio (Kobe University)H-Index: 13
Last. Akira Suzuki (Kobe University)H-Index: 67
view all 9 authors...
#1Hiroki Goto (Kobe University)H-Index: 1
#2Miki Nishio (Kobe University)H-Index: 13
Last. Akira Suzuki (Kobe University)H-Index: 67
view all 14 authors...
ABSTRACT Hippo signaling is modulated in response to cell density, external mechanical forces, and rigidity of the extracellular matrix (ECM). The Mps one binder kinase activator (MOB) adaptor proteins are core components of Hippo signaling and influence Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which are potent transcriptional regulators. YAP1/TAZ are key contributors to cartilage and bone development but the molecular mechanisms by which the...
11 CitationsSource
#1Sho Nambara (Kyushu University)H-Index: 7
#2Takaaki MasudaH-Index: 15
Last. Koshi MimoriH-Index: 62
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// Sho Nambara 1 , Takaaki Masuda 1 , Miki Nishio 2, 3 , Shotaro Kuramitsu 1 , Taro Tobo 4 , Yushi Ogawa 5 , Qingjiang Hu 1 , Tomohiro Iguchi 6 , Yousuke Kuroda 1 , Shuhei Ito 1 , Hidetoshi Eguchi 1 , Keishi Sugimachi 1, 6 , Hiroshi Saeki 7 , Eiji Oki 7 , Yoshihiko Maehara 7 , Akira Suzuki 2, 3 and Koshi Mimori 1 1 Department of Surgery, Kyushu University Beppu Hospital, Beppu, Oita 874-0838, Japan 2 Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fuku...
2 CitationsSource
#1Kohei OtsuboH-Index: 8
#2Hiroki GotoH-Index: 11
Last. Akira Suzuki (Kobe University)H-Index: 67
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MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation
14 CitationsSource
#1Norio Miyamura (Tokyo Medical and Dental University)H-Index: 7
#2Shoji Hata (Tokyo Medical and Dental University)H-Index: 23
Last. NishinaHiroshi (Tokyo Medical and Dental University)H-Index: 48
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Senescent and injured cells affect tissue functions and can drive tumorigenesis. Thus, efficient elimination of these cells is pivotal for tissue integrity. Here Miyamura et al. show that YAP acts as a cellular stress sensor and promotes the elimination of damaged cells to maintain tissue homeostasis.
17 CitationsSource
#1Sugimachi K (Kyushu University)H-Index: 92
#2Miki NishioH-Index: 13
Last. Koshi MimoriH-Index: 62
view all 14 authors...
Objective: MOB1, a core component of the Hippo signaling pathway, suppresses cell proliferation, and MOB1 liver conditional knockout mice develop intrahepatic cho
3 CitationsSource
#1Miki Nishio (Kobe University)H-Index: 13
#2Tomohiko Maehama (Kobe University)H-Index: 2
Last. Akira Suzuki (Kobe University)H-Index: 67
view all 10 authors...
The Hippo signaling pathway is a vital suppressor of tumorigenesis that is often inactivated in human cancers. In normal cells, the Hippo pathway is triggered by external forces such as cell crowding, or changes to the extracellular matrix or cell polarity. Once activated, Hippo signaling down-regulates transcription supported by the paralogous cofactors YAP1 and TAZ. The Hippo pathway's functions in normal and cancer biology have been dissected by studies of mutant mice with null or conditional...
4 CitationsSource
#1Keisuke Nakatani (Kobe University)H-Index: 2
#2Tomohiko Maehama (NIH: National Institutes of Health)H-Index: 28
Last. Akira Suzuki (Kobe University)H-Index: 67
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Abstract The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced patient survival. Thus, the Hippo pathway is an attractive anti-cancer target. Here, we provide an overview of the function and regulation of...
11 CitationsSource
#1Yuki Matsushita (Kyushu University)H-Index: 4
#2Yasunari Sakai (Kyushu University)H-Index: 20
Last. Toshiro Hara (Kyushu University)H-Index: 50
view all 13 authors...
Epilepsy is a frequent comorbidity in patients with focal cortical dysplasia (FCD). Recent studies utilizing massive sequencing data identified subsets of genes that are associated with epilepsy and FCD. AKT and mTOR-related signals have been recently implicated in the pathogenic processes of epilepsy and FCD. To clarify the functional roles of the AKT-mTOR pathway in the hippocampal neurons, we generated conditional knockout mice harboring the deletion of Pten (Pten-cKO) in Proopiomelanocortin-...
9 CitationsSource