Anke R. Hammerschlag
University of Queensland
Additive genetic effectsGenome-wide association studyOffspringPsychopathologyChild psychopathologyExplained variationPsychologyHeritabilityExpression quantitative trait lociGenetic associationBipolar disorderAggressionGeneticsGenetic correlationBiologyNeuroticism
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Publications 5
#1Alexander Neumann (Erasmus University Medical Center)H-Index: 6
#2Ilja M. Nolte (UG: University of Groningen)H-Index: 68
Last. Anke R. Hammerschlag (UQ: University of Queensland)
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Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium. The ...
#1Anke R. Hammerschlag (PHRI: Public Health Research Institute)
#2Enda M. Byrne (UQ: University of Queensland)H-Index: 35
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Abstract Background Recent genome-wide association studies (GWAS) identified the first genetic loci associated with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). The next step is to use these results to increase our understanding of the biological mechanisms involved. Most of the identified variants likely influence gene regulation. The aim of the current study is to shed light on the mechanisms underlying the genetic signals and prioritize genes by integrat...
#1Eshim S. Jami (PHRI: Public Health Research Institute)
#2Espen Moen Eilertsen (FHI: Norwegian Institute of Public Health)H-Index: 7
Last. Christel M. Middeldorp (UQ: University of Queensland)H-Index: 42
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It is unclear to what extent parental influences on the development of internalizing problems in offspring are explained by indirect genetic effects, reflected in the environment provided by the parent, in addition to the genes transmitted from parent to child. In this study, these effects were investigated using two innovative methods in a large birth cohort. Using maternal-effects genome complex trait analysis (M-GCTA), the effects of offspring genotype, maternal or paternal genotypes, and the...
#1Wonuola Akingbuwa (PHRI: Public Health Research Institute)
#2Anke R. Hammerschlag (PHRI: Public Health Research Institute)
Last. Elizabeth Diemer (Erasmus University Medical Center)
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Importance: Adult mood disorders are often preceded by behavioral and emotional problems in childhood. It is yet unclear what explains the associations between childhood psychopathology and adult traits. Objective: To investigate whether genetic risk for adult mood disorders and associated traits is associated with childhood disorders. Design, Setting, and Participants: This meta-analysis examined data from 7 ongoing longitudinal birth and childhood cohorts from the UK, the Netherlands, Sweden, ...
#1Hill F. Ip (VU: VU University Amsterdam)H-Index: 7
#2Camiel M. van der Laan (VU: VU University Amsterdam)H-Index: 1
Last. Dorret I. Boomsma (VU: VU University Amsterdam)H-Index: 142
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Childhood aggressive behavior (AGG) has a substantial heritability, with limited success in genome-wide association studies. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across age from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data - i...