Hao-Hsuan Hsieh
California Institute of Technology
Publications 1
#1Chien-I Yang (California Institute of Technology)
#2Hao-Hsuan Hsieh (California Institute of Technology)
Last.Shu-ou Shan (California Institute of Technology)H-Index: 33
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The nascent polypeptide exit site of the ribosome is a crowded environment where multiple ribosome-associated protein biogenesis factors (RPBs) compete for the nascent polypeptide to influence their localization, folding, or quality control. Here we address how N-terminal methionine excision (NME), a ubiquitous process crucial for the maturation of over 50% of the bacterial proteome, occurs in a timely and selective manner in this crowded environment. In bacteria, NME is mediated by 2 essential ...