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Fernanda M. Bosada
University of Amsterdam
GeneEnhancerEpigenomicsRegulation of gene expressionGenetic associationAtrial fibrillationGeneticsDiabetes mellitusChromatinBiology
3Publications
2H-index
11Citations
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Publications 3
Newest
#1Antoinette F. van Ouwerkerk (UvA: University of Amsterdam)H-Index: 2
#2Amelia W. Hall (Broad Institute)H-Index: 7
Last. Patrick T. Ellinor (Broad Institute)H-Index: 76
view all 16 authors...
3 CitationsSource
#1Antoinette F. van Ouwerkerk (UvA: University of Amsterdam)H-Index: 2
#2Fernanda M. Bosada (UvA: University of Amsterdam)H-Index: 2
Last. Phil Barnett (UvA: University of Amsterdam)H-Index: 25
view all 12 authors...
Rationale: Genome-wide association studies (GWAS) have identified a large number of common variants (single nucleotide polymorphisms) associated with atrial fibrillation (AF). These variants are located mainly in non-coding regions of the genome and likely include variants that modulate the function of transcriptional regulatory elements (REs) such as enhancers. However, the actual REs modulated by variants as well as the target genes of such REs remain to be identified. Thus, the biological mec...
Source
#1Antoinette F. van Ouwerkerk (UvA: University of Amsterdam)H-Index: 2
#2Fernanda M. Bosada (UvA: University of Amsterdam)H-Index: 2
Last. Vincent M. Christoffels (UvA: University of Amsterdam)H-Index: 58
view all 16 authors...
Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized....
8 CitationsSource
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