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Jieping Chen
Third Military Medical University
2Publications
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23Citations
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#1Shuzhen Zhang (Third Military Medical University)
#2Songjie Feng (ShanghaiTech University)
Last.Jieping Chen (Third Military Medical University)H-Index: 1
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#1Wen Jiang (Third Military Medical University)H-Index: 1
#2S. M. Feng (CAS: Chinese Academy of Sciences)H-Index: 4
Last.Xingxu Huang (ShanghaiTech University)H-Index: 22
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Base editor (BE), containing a cytidine deaminase and catalytically defective Cas9, has been widely used to perform base editing. However, the narrow editing window of BE limits its utility. Here, we developed a new editing technology named as base editor for programming larger C to U (T) scope (BE-PLUS) by fusing 10 copies of GCN4 peptide to nCas9(D10A) for recruiting scFv-APOBEC-UGI-GB1 to the target sites. The new system achieves base editing with a broadened window, resulting in an increased...
23 CitationsSource
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