Match!
Rosemary C. Bagot
McGill University
PsychologyTranscriptomeNeuroscienceNucleus accumbensPrefrontal cortexBiology
15Publications
6H-index
111Citations
What is this?
Publications 16
Newest
#1Aaron S. Heller (UM: University of Miami)H-Index: 19
#2Rosemary C. Bagot (McGill University)H-Index: 6
Source
#1Catherine Jensen Pena (Princeton University)H-Index: 10
#2Milo R. Smith (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Eric J. Nestler (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
view all 13 authors...
Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice, consistent with our earlier findings in male mice. We used RNA-sequencing in the ventral tegmental area, nucleus accumbens, and prefrontal cortex of male and female mice to show that adult stress is distinctly represented in the brain’s transcript...
3 CitationsSource
#1Catherine Jensen Peña (Princeton University)H-Index: 1
#2Milo R. Smith (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Eric J. Nestler (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 157
view all 13 authors...
ABSTRACT Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice, consistent with our earlier findings in male mice. We used RNA-sequencing in the ventral tegmental area, nucleus accumbens, and prefrontal cortex of male and female mice to show that adult stress is distinctly represented in the brain’s t...
Source
#1Zachary S. Lorsch (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
#2Peter J. Hamilton (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 26
Last. Eric J. Nestler (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 157
view all 28 authors...
Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zinc finger protein, is the highest-ranked key driver gene in the network, and overexpression of Zfp189 in prefrontal cortical neurons preferentially activates this network and promote...
2 CitationsSource
#1Aislinn Sandre (McGill University)H-Index: 2
#2Rosemary C. Bagot (McGill University)H-Index: 6
Last. Anna Weinberg (McGill University)H-Index: 27
view all 3 authors...
Abstract Individual differences in neural response to appetitive and aversive stimuli may confer vulnerability to stress-related psychopathology, including depression and anxiety. However, the specificity of this association with symptoms of depression and anxiety within the context of real-world stress is not well understood. The present study examined whether neural responses to appetitive and aversive images, measured by the late positive potential (LPP), prospectively predict symptoms of dep...
1 CitationsSource
#1Jessie Muir (McGill University)H-Index: 2
#2Joëlle Lopez (McGill University)H-Index: 3
Last. Rosemary C. Bagot (McGill University)H-Index: 6
view all 3 authors...
The advent of optogenetics and chemogenetics has revolutionized the study of neural circuit mechanisms of behavioral dysregulation in psychiatric disease. These powerful technologies allow manipulation of specific neurons to determine causal relationships between neuronal activity and behavior. Optogenetic tools have been key to mapping the circuitry underlying depression-like behavior in animal models, clarifying the contribution of the ventral tegmental area, nucleus accumbens, medial prefront...
8 CitationsSource
#1Catherine Jensen Pena (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 21
#2Eric J. Nestler (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 157
Last. Rosemary C. Bagot (McGill University)H-Index: 6
view all 3 authors...
Epidemiological evidence identifies early life adversity as a significant risk factor for the development of mood disorders. Much evidence points to the role of early life experience in susceptibility and, to a lesser extent, resilience, to stress in adulthood. While many models of these phenomena exist in the literature, results are often conflicting and a systematic comparison of multiple models is lacking. Here we compare effects of nine manipulations spanning the early postnatal through peri...
3 CitationsSource
#1Hannah M. Cates (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
#2Rosemary C. Bagot (McGill University)H-Index: 6
Last. Eric J. Nestler (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 157
view all 10 authors...
Drug abuse is a multifaceted disorder that involves maladaptive decision making. Long-lasting changes in the addicted brain are mediated by a complex circuit of brain reward regions. The prefrontal cortex (PFC) is one region in which chronic drug exposure changes expression and function of upstream transcriptional regulators to alter drug responses and aspects of the addicted phenotype. We reported recently that the transcription factor E2F3a is a critical mediator of cocaine responses in the nu...
3 CitationsSource
#1Zachary S. Lorsch (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
#2Yong-Hwee E. Loh (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 20
Last. Eric J. Nestler (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 157
view all 21 authors...
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated remains poorly understood. In this study, we analyze upstream regulators of genes differentially expressed after chronic social defeat stress. We identify estrogen receptor α (ERα) as the top regulator of pro-resilient transcriptional changes in the nucleus accumbens (NAc), a key ...
16 CitationsSource
#1Efrain Ribeiro (Allen Institute for Brain Science)H-Index: 8
#2Marine Salery (Allen Institute for Brain Science)H-Index: 3
Last. Eric J. Nestler (Allen Institute for Brain Science)H-Index: 157
view all 22 authors...
The role of somatostatin interneurons in nucleus accumbens (NAc), a key brain reward region, remains poorly understood due to the fact that these cells account for < 1% of NAc neurons. Here, we use optogenetics, electrophysiology, and RNA-sequencing to characterize the transcriptome and functioning of NAc somatostatin interneurons after repeated exposure to cocaine. We find that the activity of somatostatin interneurons regulates behavioral responses to cocaine, with repeated cocaine reducing th...
5 CitationsSource
12