Laura Casares
University of Dundee
NeuroprotectionCannabidiolBioinformaticsBiologyCancer cell
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Publications 3
#1Laura Casares (Dund.: University of Dundee)H-Index: 1
#2J. D. Unciti (Emerald Group Publishing)
Last. L. de la Vega (Dund.: University of Dundee)H-Index: 1
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Oxidative stress and inflammation in the brain are two key hallmarks of neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, Huntington's and multiple sclerosis. The axis NRF2-BACH1 has anti-inflammatory and anti-oxidant properties that could be exploited pharmacologically to obtain neuroprotective effects. Activation of NRF2 or inhibition of BACH1 are, individually, promising therapeutic approaches for NDs. Compounds with dual activity as NRF2 activators and BACH1 inhibitors, coul...
#1Laura Casares (Dund.: University of Dundee)H-Index: 1
Last. Eduardo Muñoz (UCO: University of Córdoba (Spain))H-Index: 40
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Abstract Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that attracted a great attention for its therapeutic potential against different pathologies including skin diseases. However, although the efficacy in preclinical models and the clinical benefits of CBD in humans have been extensively demonstrated, the molecular mechanism(s) and targets responsible for these effects are as yet unknown. Herein we characterized at the molecular level the effects of CBD on primary human kerati...
9 CitationsSource
#1Laura Torrente (Dund.: University of Dundee)H-Index: 3
#2Gunjit Maan (Dund.: University of Dundee)
Last. Laureano de la Vega (Dund.: University of Dundee)H-Index: 12
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Aberrant hyperactivation of NRF2 is a common event in many tumour types and associates with resistance to therapy and poor patient prognosis. The identification of ways to overcome the protection provided by NRF2 and selectively kill cancer cells addicted to NRF2 is a desirable goal. Exploiting the CRISPR/Cas9 technology, we generated colorectal cancer cell lines with hyperactive NRF2, and used them to perform a drug screen. We identified AT9283, an Aurora kinase inhibitor, for its selectivity t...