Laura Casares
University of Dundee
Publications 2
#1Laura Casares (Dund.: University of Dundee)
Last.Eduardo Muñoz (UCO: University of Córdoba (Spain))H-Index: 38
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Abstract Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that attracted a great attention for its therapeutic potential against different pathologies including skin diseases. However, although the efficacy in preclinical models and the clinical benefits of CBD in humans have been extensively demonstrated, the molecular mechanism(s) and targets responsible for these effects are as yet unknown. Herein we characterized at the molecular level the effects of CBD on primary human kerati...
#1Laura Torrente (Dund.: University of Dundee)H-Index: 3
#2Gunjit Maan (Dund.: University of Dundee)
Last.Laureano de la Vega (Dund.: University of Dundee)H-Index: 12
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Aberrant hyperactivation of NRF2 is a common event in many tumour types and associates with resistance to therapy and poor patient prognosis. The identification of ways to overcome the protection provided by NRF2 and selectively kill cancer cells addicted to NRF2 is a desirable goal. Exploiting the CRISPR/Cas9 technology, we generated colorectal cancer cell lines with hyperactive NRF2, and used them to perform a drug screen. We identified AT9283, an Aurora kinase inhibitor, for its selectivity t...