Daniela Grimm
Aarhus University
EndocrinologyMolecular biologyThyroid cancerRandom positioning machineMedicineBiologyCell biology
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Publications 105
The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin receptor antagonists (ERAs), such as bosentan, ambrisentan, or macitentan, slow down PAH progression and relieves symptoms. Several findings have indicated that endothelin is further involved in the pathogenesis of certain other diseases, making ERAs potentially beneficial in the treatment of various conditions. In add...
#1Markus Wehland (Otto-von-Guericke University Magdeburg)
#2Ulf Simonsen (AU: Aarhus University)H-Index: 38
Last. Daniela Grimm (Otto-von-Guericke University Magdeburg)H-Index: 39
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ABSTRACTIntroduction: Essential hypertension is a significant risk factor for cardiovascular disease, renal disease, and mortality with increasing prevalence. Despite the availability of various an...
Prostate cancer is one of the leading causes of cancer mortality in men worldwide. An unusual but unique environment for studying tumor cell processes is provided by microgravity, either in space or simulated by ground-based devices like a random positioning machine (RPM). In this study, prostate adenocarcinoma-derived PC-3 cells were cultivated on an RPM for time periods of 3 and 5 days. We investigated the genes associated with the cytoskeleton, focal adhesions, extracellular matrix, growth, s...
#1Daniela MelnikH-Index: 3
#2Jayashree SahanaH-Index: 10
Last. Marcus KrügerH-Index: 6
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Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target combinations for future therapies. By using the synthetic glucocorticoid dexamethasone (DEX), we were able to suppress spheroid formation in a culture of follicular thyroid cancer (FTC)...
#1Amalie L. PovlsenH-Index: 1
#2Daniela GrimmH-Index: 39
Last. Marcus KrügerH-Index: 6
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The renin–angiotensin–aldosterone system (RAAS) has been studied extensively, and with the inclusion of novel components, it has become evident that the system is much more complex than originally anticipated. According to current knowledge, there are two main axes of the RAAS, which counteract each other in terms of vascular control: The classical vasoconstrictive axis, renin/angiotensin-converting enzyme/angiotensin II/angiotensin II receptor type 1 (AT1R), and the opposing vasorelaxant axis, ...
1 CitationsSource
#1Mia Lindegaard Pedersen (AU: Aarhus University)
#2Marcus Krüger (Otto-von-Guericke University Magdeburg)H-Index: 6
Last. Markus Wehland (Otto-von-Guericke University Magdeburg)H-Index: 28
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#1Christian LegarthH-Index: 1
#2Daniela GrimmH-Index: 39
Last. Markus WehlandH-Index: 28
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Vitamin D plays a pivotal role in bone homeostasis and calcium metabolism. However, recent research has indicated additional beneficial effects of vitamin D on the cardiovascular system. This review aims to elucidate if vitamin D can be used as an add-on treatment in coronary artery disease (CAD). Large-scale epidemiological studies have found a significant inverse association between serum 25(OH)-vitamin D levels and the prevalence of essential hypertension. Likewise, epidemiological data have ...
Thyroid cancer is the most common endocrine malignancy. Most thyroid cancer types respond well to conventional treatment consisting of surgery and radioactive iodine (RAI) therapy. Unfortunately, some thyroid cancer types are resistant to surgical and RAI therapy. Multikinase inhibitors (MKIs) can be used in the treatment of advanced refractory thyroid cancers. The objective of this review is to give an update on MKI treatment (lenvatinib, sorafenib, sunitinib, cabozantinib, pazopanib, vandetani...
#1Christoph Buken (Otto-von-Guericke University Magdeburg)H-Index: 1
#2Jayashree Sahana (AU: Aarhus University)H-Index: 10
Last. Daniela Grimm (Otto-von-Guericke University Magdeburg)H-Index: 33
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The literature suggests morphological alterations and molecular biological changes within the cellular milieu of human cells, exposed to microgravity (µg), as many cell types assemble to multicellular spheroids (MCS). In this study we investigated juvenile normal human dermal fibroblasts (NHDF) grown in simulated µg (s-µg) on a random positioning machine (RPM), aiming to study changes in cell morphology, cytoskeleton, extracellular matrix (ECM), focal adhesion and growth factors. On the RPM, NHD...
2 CitationsSource
#1Daniela Grimm (Otto-von-Guericke University Magdeburg)H-Index: 39