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Yang Liu
Peking University
HaematopoiesisMolecular biologyProgenitor cellMutationBiochemistryComputational biologyBiologyCell biologyCRISPR
41Publications
10H-index
409Citations
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Publications 41
Newest
#1Yang Liu (PKU: Peking University)H-Index: 10
#2Yue-Yun Lai (PKU: Peking University)H-Index: 10
Last. Lu Gao (PKU: Peking University)
view all 12 authors...
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#1Shengfeng WangH-Index: 1
#2Lu XuH-Index: 1
Last. Jin Lu (PKU: Peking University)H-Index: 11
view all 11 authors...
Multiple myeloma (MM) is the second most frequent malignancy of blood and information on disease burden of MM was limited in developing countries. We aimed to estimate the prevalence and incidence of MM in China. We used data from the national urban employee and urban resident basic medical insurance from 2012 to 2016 in China. MM cases were based on the primary diagnose (ICD code, ICD for Oncology, or text of diagnosis) of patients. The crude prevalence and incidence were 6.88 per 100 000 popul...
Source
#1Zhuangzhuang Fan (PKU: Peking University)
#2Shichen Sun (PKU: Peking University)H-Index: 2
Last. Hailan Feng (PKU: Peking University)H-Index: 11
view all 9 authors...
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#1Yang Liu (PKU: Peking University)H-Index: 10
#1Yang Liu (PKU: Peking University)H-Index: 57
Last. Zengyichang (PKU: Peking University)H-Index: 27
view all 6 authors...
ATP synthase, a highly conserved multi-subunit enzyme complex having a common stoichiometry of α3β3γδϵab2c8-15, functions to supply ATP as the universal energy currency for cells. It comprises of the peripheral F1 sector (α3β3γδϵ) and the membrane-integrated Fo sector (ab2c8-15). In vitro structural analyses revealed that the C-terminal domain of the ϵ-subunit could adopt either an "inserted" or "non-inserted" state (with or without interacting with the α/β-subunits), with the former being viewe...
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#1Li Zeng (PKU: Peking University)H-Index: 3
#2Shichen Sun (PKU: Peking University)H-Index: 2
Last. Hailan Feng (PKU: Peking University)H-Index: 11
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Abstract Objectives A novel mutation (c.533 A > G; Q178R) in DLX3 gene is responsible for Tricho-Dento-Osseous (TDO) syndrome. As one of features of TDO syndrome is dentin hypoplasia, we explored the mechanism regarding dentin defects in TDO syndrome. Design hDPCs were obtained from the healthy premolars, stably expressing hDPCs were generated using recombinant lentiviruses. Quantitative methylation analysis, DNMT3B activity, CHIP, and evaluation of odonto-differentiation ability of hDPCs assays...
1 CitationsSource
#1Yang Liu (PKU: Peking University)H-Index: 57
#2HUANGXiao-jun (PKU: Peking University)H-Index: 42
Last. Yu Wang (PKU: Peking University)H-Index: 25
view all 9 authors...
In order to compare the effect between haploidentical (HID) stem cell transplantation (HSCT) and matched sibling donor (MSD) stem cell transplantation for high-risk acute myeloid leukemia (AML) in first complete remission status (CR1), we retrospectively studied 170 cases who received stem cell transplantation from Jan 2008 to Jul 2015 in Peking University People’s Hospital. We divided all cases into MSD group (43 cases) and HID (127 cases) group. Patients in HID and MSD group displayed similar ...
3 CitationsSource
#1Shichen Sun (PKU: Peking University)H-Index: 2
#2Fang Li (PKU: Peking University)H-Index: 2
Last. Dong Han (PKU: Peking University)H-Index: 9
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Abstract Objective: To explore the gene mutation in an incontinentia pigmenti (IP) patient with syndromic tooth agenesis. Methods: Long-range polymerase chain reaction (PCR) and Sanger sequencing were used to detect inhibitor of nuclear factor kappa-B kinase subunit gamma (IKBKG) mutation in the IP patient. We used the nuclear factor kappa B (NF-κB) reporter gene to assess activation of NF-κB, after transfecting an empty vector, wild-type, or mutant NF-κB essential modulator (NEMO) plasmid into ...
1 CitationsSource
#1Xinmiao Fu (Fujian Normal University)H-Index: 20
#2Yan Wang (Fujian Normal University)H-Index: 2
Last. Zengyichang (PKU: Peking University)H-Index: 27
view all 8 authors...
Abstract Protein-protein interaction, including protein homo-oligomerization, is commonly believed to occur through a specific interface made of a limited number of amino acid residues. Here our systematic in vivo photo-crosslinking analysis via genetically incorporated unnatural amino acids unexpectedly shows that the dimerization of HdeA, an acid stress chaperone, is mediated by the residues along its whole polypeptide. These include those “forbidden” residues that are far away from the dimeri...
2 CitationsSource
#1Jianhang Yin (PKU: Peking University)H-Index: 1
#2Mengzhu Liu (PKU: Peking University)H-Index: 1
Last. Jiazhi Hu (PKU: Peking University)H-Index: 12
view all 9 authors...
Efficient and precise genome editing is essential for clinical applications and generating animal models, which requires engineered nucleases with high editing ability while low off-target activity. Here we present a high-throughput sequencing method, primer-extension-mediated sequencing (PEM-seq), to comprehensively assess both editing ability and specificity of engineered nucleases. We showed CRISPR/Cas9-generated breaks could lead to chromosomal translocations and large deletions by PEM-seq. ...
1 CitationsSource
#1Jiayu Yu (PKU: Peking University)H-Index: 3
#2Yang Liu (PKU: Peking University)H-Index: 57
Last. Zengyichang (PKU: Peking University)H-Index: 27
view all 4 authors...
Bacteria have long been recognized to be capable of entering a phenotypically non-growing persister state, in which the cells exhibit an extended regrowth lag and a multidrug tolerance, thus posing a great challenge in treating infectious diseases. Owing to their non-inheritability, low abundance of existence, lack of metabolic activities, and high heterogeneity, properties of persisters remain poorly understood. Here, we report our accidental discovery of a subcellular structure that we term th...
2 CitationsSource
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