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Nadia S. Kurd
University of California, San Diego
Intraepithelial lymphocyteCD8T-cell receptorT cellPopulationThymic TissueNegative selectionBiologyImmune system
3Publications
1H-index
2Citations
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Publications 3
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#1J. Justin Milner (UCSD: University of California, San Diego)H-Index: 5
#2Clara Toma (UCSD: University of California, San Diego)H-Index: 3
Last. John T. Crowl (UCSD: University of California, San Diego)H-Index: 1
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Summary Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and genetic reporter mice, we identified discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that...
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#1Nadia S. Kurd (UCSD: University of California, San Diego)H-Index: 1
#2Zhaoren He (UCSD: University of California, San Diego)H-Index: 3
Last. Jocelyn G. Olvera (UCSD: University of California, San Diego)H-Index: 2
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During an immune response to microbial infection, CD8+ T cells give rise to distinct classes of cellular progeny that coordinately mediate clearance of the pathogen and provide long-lasting protection against reinfection, including a subset of noncirculating tissue-resident memory (TRM) cells that mediate potent protection within nonlymphoid tissues. Here, we used single-cell RNA sequencing to examine the gene expression patterns of individual CD8+ T cells in the spleen and small intestine intra...
1 CitationsSource
#1Nadia S. Kurd (UCSD: University of California, San Diego)H-Index: 1
#2Zhaoren He (UCSD: University of California, San Diego)H-Index: 3
Last. Tiffani Tysl (UCSD: University of California, San Diego)H-Index: 2
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During an immune response to microbial infection, CD8+ T cells give rise to distinct classes of cellular progeny that coordinately mediate clearance of the pathogen and provide long-lasting protection against reinfection, including a subset of non-circulating tissue-resident memory (TRM) cells that mediate potent protection within non-lymphoid tissues. Here, we utilized single-cell RNA-sequencing to examine the gene expression patterns of individual CD8+ T cells in the spleen and small intestine...
1 CitationsSource
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