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Roy Lardenoije
Maastricht University
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#1Magdalena T. Weidner (University of Würzburg)H-Index: 1
#2Roy Lardenoije (UM: Maastricht University)H-Index: 1
Last.Klaus-Peter Lesch (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 101
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Converging evidence suggests a role of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme of 5-HT synthesis in the brain, in modulating long-term, neurobiological effects of early-life adversity. Here, we aimed at further elucidating the molecular mechanisms underlying this interaction, and its consequences for socio-emotional behaviors, with a focus on anxiety and social interaction. In this study, adult, male Tph2 null mutant (Tph2 (-/-)) and he...
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