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Jun Hui Sze
Griffith University
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#1Jun Hui Sze (Griffith University)
#2Prahlad Raninga (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 1
Last.Kathryn Fay Tonissen (Griffith University)H-Index: 18
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Abstract Multiple myeloma (MM), the second most common haematological malignancy, is a clonal plasma B-cell neoplasm that forms within the bone marrow. Despite recent advancements in treatment, MM remains an incurable disease. Auranofin, a linear gold(I) phosphine compound, has previously been shown to exert a significant anti-myeloma activity by inhibiting thioredoxin reductase (TrxR) activity. A bis-chelated tetrahedral gold(I) phosphine complex [Au(d2pype)2]Cl (where d2pype is 1,2-bis(di-2-py...
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