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Luanluan Sun
University of Cambridge
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#1Luanluan Sun (University of Cambridge)
#2Lisa Pennells (University of Cambridge)H-Index: 12
Last.Emanuele Di Angelantonio (University of Cambridge)H-Index: 54
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Background: There is debate about the value of adding information on genetic and other molecular markers to conventional cardiovascular disease (CVD) risk predictors. Methods: Using data on 306,654 individuals without a history of CVD from UK Biobank, we calculated measures of risk-discrimination and reclassification upon addition of polygenic risk scores (PRS) and a panel of 27 clinical biochemistry markers to a conventional risk prediction model (i.e., including age, sex, systolic blood pressu...
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