K. Kruczek
National Institutes of Health
Publications 1
Published in bioRxiv
Koray Dogan Kaya6
Estimated H-index: 6
(NIH: National Institutes of Health),
Hsiu-Chuan Chen2
Estimated H-index: 2
(NIH: National Institutes of Health)
+ -3 AuthorsK. Kruczek (NIH: National Institutes of Health)
Retinal organoids generated from human pluripotent stem cells exhibit considerable variability in temporal dynamics of differentiation. To assess the maturity of neural retina in vitro, we performed transcriptome analyses of developing organoids from human embryonic and induced pluripotent stem cell lines. We show that the developmental variability in organoids was reflected in gene expression profiles and could be evaluated by molecular staging with the human fetal and adult retinal transcripto...