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Huixin Li
Shenyang Pharmaceutical University
PharmacokineticsPhysiologically based pharmacokinetic modellingPiroxicamIVIVCBioequivalence
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#1Huixin Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Sirun Lu (SPU: Shenyang Pharmaceutical University)
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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AbstractRaloxifene hydrochloride (RH) suffers from low oral bioavailability due to its low water-solubility and first-pass metabolism. Therefore, a novel phospholipid complex of RH (RHPC) and a mat...
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#1Xiaoting Li (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Yuanhang Yang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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A quantitative prediction of human pharmacokinetic (PK) profiles has become an increasing demand for the reduction of the clinical failure of drug formulations. The existing in vitro and in vivo correlation (IVIVC) methodology could achieve this goal, but the development of IVIVC for immediate release (IR) products is challenging. Herein, we report that for certain weakly acidic biopharmaceutical classification system (BCS) class II molecules (piroxicam, PIRO), physiologically based PK (PBPK) mo...
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