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Zhengkai Wei
Foshan University
Neutrophil extracellular trapsNeutrophil elastaseNADPH oxidaseExtracellularReactive oxygen speciesMAPK/ERK pathway
5Publications
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Publications 6
Newest
#1Zhengkai Wei (FOSU: Foshan University)
#2Tingting Yu (JLU: Jilin University)
Last. Zhengtao Yang (FOSU: Foshan University)H-Index: 1
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#1Jingjing Wang (FOSU: Foshan University)H-Index: 9
#2Zhengkai Wei (FOSU: Foshan University)
Last. Zhengtao Yang (FOSU: Foshan University)H-Index: 1
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Abstract In recent years, numerous studies paid more attention to the molecular mechanisms associated with fluoride toxicity. However, the detailed mechanisms of fluoride immunotoxicity in bovine neutrophils remain unclear. Neutrophil extracellular traps (NETs) is a novel immune mechanism of neutrophils. We hypothesized that sodium fluoride (NaF) can trigger NETs activation and release, and investigate the related molecular mechanisms during the process. We exposed peripheral blood neutrophils t...
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#1Aimin Jiang (JLU: Jilin University)H-Index: 1
#2Yong Zhang (JLU: Jilin University)H-Index: 1
Last. Zhengtao Yang (FOSU: Foshan University)H-Index: 24
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Abstract Mastitis is a common veterinary clinical disease that restricts the development of dairy farming around the world. Morin, extracted from Mulberry Tree and other herbs, has been reported to possess the function of anti-bacteria, anti-oxidant, and anti-inflammatory. However, whether morin could protect lipopolysaccharide (LPS)-induced mouse mastitis in vivo has not well known. This study firstly aims to evaluate the effects of morin on LPS-induced mouse mastitis in vivo, and then try to i...
1 CitationsSource
#1Xiao LiuH-Index: 2
#2Yanan WangH-Index: 5
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Alcoholic liver damage (ALD) is a toxic liver damage caused by excessive drinking. Oxidative stress is one of the most crucial pathogenic factors leading to ALD. Magnolol is one of the main active constituents of traditional Chinese medicine Magnolia officinalis, which has been reported to possess many pharmacological effects including anti-inflammatory, anti-oxidantand anti-tumor. However, the effects of magnolol on ALD remain unclear. In this study, we firstly evaluated the protective effects ...
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#1Chaoqun Wang (FOSU: Foshan University)H-Index: 1
#2Xiao Liu (JLU: Jilin University)H-Index: 2
Last. Zhengkai Wei (FOSU: Foshan University)
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Abstract As a new type of antibacterial agent, nanosilver has attracted great attention in biomedical applications. However, the safety of nanosilver to humans and the environment has not been well elucidated. The objective of this study was to investigate the influence of nanosilver on novel effector mechanism of neutrophil extracellular traps (NETs), and its possible molecular mechanisms. In this study, nanosilver (10, 20 and 40 μg/mL) was incubated with neutrophils for 90 min. Then, nanosilve...
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#1Zhen Han (FOSU: Foshan University)H-Index: 1
#2Yong Zhang (FOSU: Foshan University)H-Index: 1
Last. Zhengkai Wei (FOSU: Foshan University)
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Ochratoxin A (OTA) is a mycotoxin which could cause strong immunosuppressive toxicological effects in animals and humans. Heterophil extracellular traps (HETs) as a novel defense of chicken heterophils play an important role against pathogen infection. It has been reported that OTA can weaken the phagocytosis function of neutrophils. However, whether or not OTA shows immunosuppressive effects on HET release remains unclear. In the present study, we aim to first investigate the effects of OTA on ...
1 CitationsSource
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