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Pierre-Olivier Duroy
University of Lausanne
2Publications
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#1Pierre-Olivier Duroy (UNIL: University of Lausanne)H-Index: 1
#2Sandra Bosshard (UNIL: University of Lausanne)H-Index: 2
Last.Nicolas Mermod (UNIL: University of Lausanne)H-Index: 34
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#1Sandra Bosshard (UNIL: University of Lausanne)H-Index: 2
#2Pierre-Olivier Duroy (UNIL: University of Lausanne)H-Index: 1
Last.Nicolas Mermod (UNIL: University of Lausanne)H-Index: 34
view all 3 authors...
Abstract CRISPR technologies greatly foster genome editing in mammalian cells through site-directed DNA double strand breaks (DSBs). However, precise editing outcomes, as mediated by homologous recombination (HR) repair, are typically infrequent and outnumbered by undesired genome alterations. By using knockdown and overexpression studies in Chinese hamster ovary (CHO) cells as well as characterizing repaired DNA junctions, we found that efficient HR-mediated genome editing depends on alternativ...
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