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K. Muniyappa
Indian Institute of Science
Homologous recombinationGeneDNA repairMutantMycobacterium smegmatisBiologyCell biology
2Publications
1H-index
2Citations
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Publications 2
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#1Deepika Prasad (IISc: Indian Institute of Science)H-Index: 1
#2Divya AroraH-Index: 4
Last. K. Muniyappa (IISc: Indian Institute of Science)H-Index: 1
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The RecX protein has attracted considerable interest because the recX mutants exhibit multiple phenotypes associated with RecA functions. To further our understanding of the functional relationship between recA and recX, the effect of different stress treatments on their expression profiles, cell yield and viability were investigated. A significant correlation was found between the expression of Mycobacterium smegmatis recA and recX genes at different stages of growth, and in response to differe...
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#1Kasi ManikandanH-Index: 2
#2Deepika Prasad (IISc: Indian Institute of Science)H-Index: 1
Last. Krishna M. SinhaH-Index: 18
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Cyclic di-GMP and cyclic di-AMP are second messengers produced by a wide variety of bacteria. They influence bacterial cell survival, biofilm formation, virulence and bacteria-host interactions. However, many of their cellular targets and biological effects are yet to be determined. A chemical proteomics approach revealed that Mycobacterium smegmatis RecA (MsRecA) possesses a high-affinity cyclic di-AMP binding activity. We further demonstrate that both cyclic di-AMP and cyclic di-GMP bind speci...
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