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Stavros Droubogiannis
University of Crete
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#1Zoe Petraki (UoC: University of Crete)H-Index: 4
#2Stavros Droubogiannis (UoC: University of Crete)
Last.Cleanthe Spanaki (UoC: University of Crete)H-Index: 20
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Abstract Glutamate dehydrogenase 1 (GDH1) contributes to glucose-stimulated insulin secretion in murine β-cells, but not to basic insulin release. The implications of these findings for human biology are unclear as humans have two GDH-specific enzymes: hGDH1 (GLUD1-encoded) and hGDH2 (GLUD2-encoded), a novel enzyme that is highly activated by ADP and L-leucine. Here we studied in vivo glucose homeostasis in transgenic (Tg) mice generated by inserting the GLUD2 gene and its putative regulatory el...
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