Stefan Zeuzem
Goethe University Frankfurt
Publications 7
#1Stefan Zeuzem (Goethe University Frankfurt)H-Index: 5
#2Stefan BourgeoisH-Index: 10
Last.Michael Biermer (Janssen Pharmaceutica)H-Index: 1
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1 CitationsSource
4 CitationsSource
#1Dirk H. Walter (Goethe University Frankfurt)H-Index: 25
#2Patrick N. Harter (DKFZ: German Cancer Research Center)H-Index: 24
Last.Oliver Waidmann (DKFZ: German Cancer Research Center)H-Index: 22
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Data on intratumoral heterogeneity of small intestine neuroendocrine tumors (SI-NETs) and related liver metastasis are limited. The aim of this study was to characterize genetic heterogeneity of 5 patients with SI-NETs. Therefore, formalin-fixed, paraffin-embedded tissue samples of primary and metastatic lesions as well as benign liver of five patients with synchronously metastasized, well differentiated SI-NETs were analyzed with whole exome sequencing. For one patient, chip based 850k whole DN...
5 CitationsSource
#1Dirk H. WalterH-Index: 25
#2Claudia DöringH-Index: 20
Last.Jan Peveling-OberhagH-Index: 14
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// Dirk Walter 1, 2 , Claudia Doring 2 , Magdalena Feldhahn 3 , Florian Battke 3 , Sylvia Hartmann 2 , Ria Winkelmann 2 , Markus Schneider 2 , Katrin Bankov 1 , Andreas Schnitzbauer 4 , Stefan Zeuzem 1 , Martin Leo Hansmann 2 , Jan Peveling-Oberhag 1, 2, 5 1 Department of Internal Medicine I, Johann Wolfgang Goethe-University Hospital, 60590 Frankfurt, Germany 2 Dr. Senckenberg Institute of Pathology, Johann Wolfgang Goethe-University Hospital, 60590 Frankfurt, Germany 3 CeGaT GmbH, 72076 Tuebin...
9 CitationsSource
#1Sylvie Deuffic–Burban (French Institute of Health and Medical Research)H-Index: 1
#2Pierre DeltenreH-Index: 26
Last.Philippe Mathurin (university of lille)H-Index: 16
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Background & Aims The dynamics of hepatitis C virus (HCV) infection, as well as screening practices and access to therapy, vary among European countries. It is important to determine the magnitude of the effects of such differences on incidence and mortality of infection. We compared the dynamics of infection and screening and treatment practices among Belgium, France, Germany, Italy, Spain, and the United Kingdom. We also assessed the effects of treatment with pegylated interferon and additiona...
95 CitationsSource
#1Stefan Zeuzem (Goethe University Frankfurt)H-Index: 5
#2Peter BuggischH-Index: 27
Last.Graham R. Foster (QMUL: Queen Mary University of London)H-Index: 62
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Tegobuvir (GS-9190), a non-nucleoside nonstructural protein (NS)5B polymerase inhibitor, and GS-9256, an NS3 serine protease inhibitor, individually have activity against hepatitis C virus (HCV) genotype 1. The antiviral activity of tegobuvir and GS-9256 as oral combination therapy, or together with ribavirin (RBV) or pegylated interferon (Peg-IFN) alpha-2a and RBV, was assessed in a phase II, randomized, open-label trial. Treatment-naive patients with genotype 1 HCV were assigned 28 days of teg...
97 CitationsSource
Methods In this randomized, phase 3 trial, we evaluated the addition of telaprevir to peginter feron alfa-2a plus ribavirin in patients with HCV genotype 1 infection who had no response or a partial response to previous therapy or who had a relapse after an initial response. A total of 663 patients were assigned to one of three groups: the T12PR48 group, which received telaprevir for 12 weeks and peginterferon plus ribavirin for a total of 48 weeks; the lead-in T12PR48 group, which received 4 we...
1,359 CitationsSource