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Harry Kane
Trinity College, Dublin
PKM2Innate immune systemAdipose tissueInflammationImmunityPyruvate kinaseBiologyImmune systemCell biology
2Publications
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3Citations
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Publications 3
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#1Cathal HarmonH-Index: 6
Last. Lydia LynchH-Index: 24
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#1Stefano Angiari (Trinity College, Dublin)H-Index: 3
#2Marah C Runtsch (Trinity College, Dublin)H-Index: 2
Last. Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
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Summary Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 has been shown to control macrophage metabolic remodeling in inflammation, but its role in T cell biology is poorly understood. Here, we report PKM2 upregulation, phosphorylation, and nuclear accumulation in murine and human CD4+ T cells following activation in vitro. Treatment of...
6 CitationsSource
#1Harry Kane (Trinity College, Dublin)H-Index: 1
#2Lydia Lynch (Trinity College, Dublin)H-Index: 24
Adipose tissue is a critical regulator of systemic metabolism and normal bodily homeostasis. Recently, the immune system has been implicated in the regulation of adipose tissue homeostasis and function. Here, we highlight new insights into the distinct phenotypes and functions of adipose resident leukocytes, including a growing body of work on their role in adipose tissue remodeling and thermogenesis. We discuss how the protective capacity of the adipose immune system can be diminished during ob...
2 CitationsSource
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