João A. Lopes
University of the Algarve
Publications 3
#1João M.A. Santos (University of the Algarve)H-Index: 2
#2Leonardo Mendes-Silva (University of the Algarve)H-Index: 1
Last.José Bragança (University of the Algarve)H-Index: 16
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Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs cardiac differentiation. We have now determined that Cited2 depletion in ESC affects the expression of transcription factors and cardiopoietic genes involved in early mesoderm and cardiac specification. Interestingly, the supplementation of the ...
1 CitationsSource
#1José BragançaH-Index: 16
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The CITED family of transcriptional modulators plays multiple roles in the development of vertebrates. These proteins are characterized by the conservation of a carboxy-terminal domain which defines this family and has a high affinity for the transcriptional co-activators CBP/p300. In humans, mutations in some CITED genes or deregulation of their expression are associated with developmental anomalies. In particular, CITED2 dysfunction has been associated with congenital heart disease. Although m...