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Daniel B. Haack
University of California, San Diego
DNA IntegrationSpliceosomeRNA splicingGroup II intronRibozyme
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#1Daniel B. Haack (UCSD: University of California, San Diego)H-Index: 1
#2Xiaodong Yan (UCSD: University of California, San Diego)H-Index: 10
Last. Navtej Toor (UCSD: University of California, San Diego)H-Index: 12
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Summary Group II introns are a class of retroelements that invade DNA through a copy-and-paste mechanism known as retrotransposition. Their coordinated activities occur within a complex that includes a maturase protein, which promotes splicing through an unknown mechanism. The mechanism of splice site exchange within the RNA active site during catalysis also remains unclear. We determined two cryo-EM structures at 3.6-A resolution of a group II intron reverse splicing into DNA. These structures ...
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