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Ya-Ju Chang
Columbia University
Induced pluripotent stem cellBiologyCell biologyCRISPR
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#1Ya-Ju Chang (Columbia University)H-Index: 1
#2Christine L. Xu (Columbia University)H-Index: 5
Last. Stephen H. Tsang (Columbia University)H-Index: 42
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: Induced pluripotent stem cells (iPSCs) have demonstrated tremendous potential in numerous disease modeling and regenerative medicine-based therapies. The development of innovative gene transduction and editing technologies has further augmented the potential of iPSCs. Cas9-cytidine deaminases, for example, have developed as an alternative strategy to integrate single-base mutations (C → T or G → A transitions) at specific genomic loci. In this chapter, we specifically describe CRISPR (clustere...
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