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Poovitha Sundar
Indian Institute of Technology Madras
GeneHMG-CoA reductaseChromatin immunoprecipitationReductaseEssential hypertension
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#1Abrar Ali Khan (Indian Institute of Technology Madras)H-Index: 3
#2Poovitha Sundar (Indian Institute of Technology Madras)
Last. Nitish R. Mahapatra (Indian Institute of Technology Madras)H-Index: 22
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3-Hydroxy-3-methyl glutaryl-coenzyme A reductase (Hmgcr) encoding the rate-limiting enzyme in the cholesterol biosynthesis pathway is a candidate gene for essential hypertension (EH). However, the regulation of Hmgcr in rat models of hypertension (viz. Spontaneously Hypertensive Rats [SHR] and its normotensive control Wistar/Kyoto [WKY] strain) is unknown. Here, we show that Hmgcr transcript and protein levels are diminished in liver tissues of SHR as compared to WKY. Consistently, a number of o...
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