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Agnese Serafini
Francis Crick Institute
GluconeogenesisPathogenMycobacterium tuberculosisBacteriaMetabolismBiology
4Publications
2H-index
11Citations
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Publications 4
Newest
#1Agnese Serafini (Francis Crick Institute)H-Index: 2
#2Lendl Tan (UQ: University of Queensland)H-Index: 4
Last. Luiz Pedro S. de Carvalho (Francis Crick Institute)H-Index: 2
view all 17 authors...
Bacterial nutrition is an essential aspect of host–pathogen interaction. For the intracellular pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans, fatty acids derived from lipid droplets are considered the major carbon source. However, many other soluble nutrients are available inside host cells and may be used as alternative carbon sources. Lactate and pyruvate are abundant in human cells and fluids, particularly during inflammation. In this work, we study ...
4 CitationsSource
#1Yoshikazu Kawai (Newcastle University)H-Index: 15
#2Romain Mercier (AMU: Aix-Marseille University)H-Index: 13
Last. Jeff Errington (Newcastle University)H-Index: 61
view all 6 authors...
The peptidoglycan cell wall is an essential structure for the growth of most bacteria. However, many are capable of switching into a wall-deficient L-form state in which they are resistant to antibiotics that target cell wall synthesis under osmoprotective conditions, including host environments. L-form cells may have an important role in chronic or recurrent infections. The cellular pathways involved in switching to and from the L-form state remain poorly understood. This work shows that the la...
3 CitationsSource
#1Aleksandra Agapova (Francis Crick Institute)H-Index: 1
#2Agnese Serafini (Francis Crick Institute)H-Index: 2
Last. Luiz Pedro S. de Carvalho (Francis Crick Institute)H-Index: 11
view all 7 authors...
Tuberculosis is an infectious disease caused by a bacterium called Mycobacterium tuberculosis. It is currently the leading cause of death by a single microbe worldwide, claiming the lives of 1.5 million people annually. The disease is difficult to cure, as many strains of the bacterium have developed resistance to the main drugs used to treat the infection. This leaves physicians with few options to treat tuberculosis and control its spread. The spread of these drug-resistant strains is a major ...
4 CitationsSource
#1Aleksandra Agapova (Francis Crick Institute)H-Index: 1
#2Agnese Serafini (Francis Crick Institute)H-Index: 2
Last. Luiz Pedro S. de Carvalho (Francis Crick Institute)H-Index: 11
view all 7 authors...
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