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Min Gao
Baylor College of Medicine
Homologous recombinationMolecular biologyGeneticsDNABiology
17Publications
9H-index
644Citations
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Publications 17
Newest
#1Yanlin He (BCM: Baylor College of Medicine)H-Index: 11
#2Pingwen Xu (BCM: Baylor College of Medicine)H-Index: 12
Last. Kenji Saito (BCM: Baylor College of Medicine)H-Index: 12
view all 23 authors...
Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these glucose-sensing neurons are unclear. Here we report that estrogen receptor-α (ERα)-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (vlVMH) can sense glucose fluctuations, being glucose-inhibited neurons (GI-ERαvlVMH) or glucose-excited neurons (GE-ERαvlVMH). Hypoglycemia activates GI-ERαvlVMH neurons via the anoctamin ...
Source
#1Daniel DiToro (UAB: University of Alabama at Birmingham)H-Index: 5
#2Stacey N. Harbour (UAB: University of Alabama at Birmingham)H-Index: 4
Last. Henrietta Turner (UAB: University of Alabama at Birmingham)H-Index: 9
view all 18 authors...
Appropriate balance of T helper 17 (Th17) and regulatory T (Treg) cells maintains immune tolerance and host defense. Disruption of Th17-Treg cell balance is implicated in a number of immune-mediated diseases, many of which display dysregulation of the insulin-like growth factor (IGF) system. Here, we show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system. Signaling through IGF receptor (IGF1R) activated the protein kinase B-mamma...
Source
#1Peng Xu (UAB: University of Alabama at Birmingham)H-Index: 1
#2Timothy Kennell (UAB: University of Alabama at Birmingham)H-Index: 2
Last. Zechen Chong (UAB: University of Alabama at Birmingham)H-Index: 17
view all 5 authors...
MOTIVATION: Meiotic recombination facilitates the transmission of exchanged genetic material between homologous chromosomes and plays a crucial role in increasing the genetic variations in eukaryotic organisms. In humans, thousands of crossover events have been identified by genotyping related family members. However, most of these crossover regions span tens to hundreds of kb, which is not sufficient resolution to accurately identify the crossover breakpoints in a typical trio family. RESULTS: ...
1 CitationsSource
#1Duy Pham (UAB: University of Alabama at Birmingham)H-Index: 2
#2Carson E. Moseley (UAB: University of Alabama at Birmingham)H-Index: 5
Last. Robin D. Hatton (UAB: University of Alabama at Birmingham)H-Index: 20
view all 10 authors...
Summary The basic leucine zipper transcription factor activating transcription factor-like (Batf) contributes to transcriptional programming of multiple effector T cells and is required for T helper 17 (Th17) and T follicular helper (Tfh) cell development. Here, we examine mechanisms by which Batf initiates gene transcription in developing effector CD4 T cells. We find that, in addition to its pioneering function, Batf controls developmentally regulated recruitment of the architectural factor Ct...
2 CitationsSource
#1Narkhyun Bae (University of Texas MD Anderson Cancer Center)H-Index: 3
#2Min Gao (University of Texas MD Anderson Cancer Center)H-Index: 9
Last. Mark T. Bedford (University of Texas MD Anderson Cancer Center)H-Index: 61
view all 7 authors...
Abstract Spindlin1 (SPIN1) is a transcriptional coactivator with critical functions in embryonic development and emerging roles in cancer. SPIN1 harbors three Tudor domains, two of which engage the tail of histone H3 by reading the H3–Lys-4 trimethylation and H3–Arg-8 asymmetric dimethylation marks. To gain mechanistic insight into how SPIN1 functions as a transcriptional coactivator, here we purified its interacting proteins. We identified an uncharacterized protein (C11orf84), which we renamed...
1 CitationsSource
#2Xi ShenH-Index: 10
Last. Lei LiH-Index: 41
view all 11 authors...
Abstract In response to DNA crosslinking damage, the Fanconi anemia (FA) core complex activates the FA pathway by monoubiquitinating Fanconi anemia complementation group D2 (FANCD2) for the initiation of the nucleolytic processing of the DNA crosslinks and stabilization of stalled replication forks. Given that all the classic FA proteins coordinately monoubiquitinate FANCD2, it is unclear why losses of individual classic FA genes yield varying cellular sensitivities to crosslinking damage. To ad...
2 CitationsSource
#1Xu Li (University of Texas MD Anderson Cancer Center)H-Index: 17
#2Min Gao (University of Texas MD Anderson Cancer Center)H-Index: 9
Last. Junjie Chen (University of Texas MD Anderson Cancer Center)H-Index: 81
view all 12 authors...
: Neurofibromin (NF1) is a well known tumor suppressor that is commonly mutated in cancer patients. It physically interacts with RAS and negatively regulates RAS GTPase activity. Despite the importance of NF1 in cancer, a high quality endogenous NF1 interactome has yet to be established. In this study, we combined clustered, regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated gene knock-out technology with affinity purification using antibodies against endogenous proteins, fol...
4 CitationsSource
#1Zechen ChongH-Index: 17
#2Jue RuanH-Index: 23
Last. Ken ChenH-Index: 37
view all 11 authors...
The novoBreak software provides sensitive, accurate, and comprehensive detection of structural variation in somatic next-generation sequencing data.
44 CitationsSource
#1Kai Zhang (Cornell University)H-Index: 6
#2Min Gao (BCM: Baylor College of Medicine)H-Index: 9
Last. Lidong Qin (Cornell University)H-Index: 29
view all 7 authors...
Single-cell transcriptome sequencing highly requires a convenient and reliable method to rapidly isolate a live cell into a specific container such as a PCR tube. Here, we report a modular single-cell pipette (mSCP) consisting of three modular components, a SCP-Tip, an air-displacement pipette (ADP), and ADP-Tips, that can be easily assembled, disassembled, and reassembled. By assembling the SCP-Tip containing a hydrodynamic trap, the mSCP can isolate single cells from 5–10 cells per μL of cell ...
5 CitationsSource
#1Xu Li (University of Texas MD Anderson Cancer Center)H-Index: 17
#2Wenqi Wang (University of Texas MD Anderson Cancer Center)H-Index: 23
Last. Junjie Chen (University of Texas MD Anderson Cancer Center)H-Index: 81
view all 9 authors...
Summary By combining the results of a large-scale proteomic analysis of the human transcription factor interaction network with knowledge databases, we identified FOXR2 as one of the top-ranked candidate proto-oncogenes. Here, we show that FOXR2 forms a stable complex with MYC and MAX and subsequently regulates cell proliferation by promoting MYC's transcriptional activities. We demonstrate that FOXR2 is highly expressed in several breast, lung, and liver cancer cell lines and related patient tu...
10 CitationsSource
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